麻醉犬心房内注射复方川芎汤后血清中川芎嗪药时曲线双峰与血流动力学效应的关系

Relationship between double-peak of concentration-time curve of serum tetramethylpyrazine and hemodynamic effect following atrial compound formula ligustici wallichii franch decoction to the anesthetized dog

目的 探讨中药大复方体内作用规律 ,为“证治药动学”6要素中“定性定量论”提供进一步的实验依据 .方法 分别从冠状动脉定量狭窄犬和对照犬的右心房内给予复方川芎水提液 (0 .6 g· kg- 1 ) .结果 在动脉血药时 (c- t)曲线上出现了川芎嗪 (TMP)的双峰现象 ;冠状动脉狭窄犬的 TMP第 2峰显著地高于对照犬 ;而这种增高的第 2峰又与 TMP的血流动力学效应相关 .

AIM To explore the action mechanism of traditional Chinese medicine (TCM) remedy in vivo , and to provide further experimental evidence for “qualitative and quantitative view”, the one of six key elements of “TCM syndrome and recipe” hypothesis. METHODS Boiled water extract of TCMR of Ligustici wallichii Franch was administered to the atria of healthy dogs and the dogs with coronary artery stenosis respectively. RESULTS Double-peak phenomena of concentration-time curve tetramethylpyrazine (TMP) in serum were observed; the second peak of TMP concentration in serum of the dog with coronary artery stenosis, which was related to the increase in coronary blood flow, was higher than that in the healthy dog ( P <0.05). CONCLUSION There is likely particular effects of physiological and pathophysiological state on the blood drug concentration of TCMR.