摘要
铜是维持哺乳动物正常生理活动的微量元素,体内铜的含量与细胞呼吸、自由基防御、血管生成、神经细胞和机体的生长发育有密切关系,它还参与脑生理活动的调节.体内铜的含量、转运及分布都受到精密的调控,铜元素缺乏和过量时都严重影响机体健康.铜及铜相关酶生物系统中对生命过程有着重要的作用,其代谢异常往往会导致严重的神经症状和神经系统疾病.本文将综述铜代谢紊乱对脑神经系统疾病的影响.
Copper （Cu） is an essential trace element for mammalian physiological activities. Copper is closely allied with cellular respiration, free radical defense, angiogenesis, the development of neurocyte and body. Some brain physiological functions are known to be copper-dependent. The concentration, transport and distribution of copper are subjected to precise regulation in the body. Copper deficiency or excess may lead seriously diseases. Copper and cuproenzymes play an important role in mammalian, copper metabolism disorder may cause severe neurological symptoms and neurological diseases. The relation of copper metabolism disorders and neurological diseases is briefly discussed.
出处
《汕头大学学报（自然科学版）》
2012年第3期54-60,共7页
Journal of Shantou University：Natural Science Edition
基金
国家自然科学基金资助项目(NSFC:60971075
30930027)
广东省自然科学基金(S2011010005194)
汕头大学科研启动基金资助项目(NTF10010)
关键词
铜代谢
神经系统疾病
神经受体
copper metabolism
nervous system disease
nerve receptor
