EP和CAP方案治疗老年人中晚期非小细胞肺癌的临床疗效观察

A Comparison of the Therapeutic Effects of EP and CAP Regimen for Treatment of Advanced Non-small Cell Lung Cancer of Older Patient

目的 比较EP方案 (Vp 16胶囊 ,DDP)与CAP方案 (CTX、ADM与DDP)治疗非小细胞肺癌的疗效。方法 6 0例晚期非小细胞肺癌随机分成两组、各 30例。结果 EP组有效率为38 8%、CAP组为 33 3% ,两组间疗效无显著性差异 (P >0 0 5)。CAP组消化系统毒性作用及脱发反应较EP组严重、造血系统毒性反应相似。结论 两方案可作为老年人非小细胞肺癌一线方案 ,DDP、Vp 16胶囊方案易行、毒副反应小、耐受性好。

Objective To evaluate the curative effects of EP (oral Vp 16 capsule+DDP)regimen and CAP(CTX+ADM+DDP)regimen on non small cell lung Cancer of older patient.Methods 60 cases of advanced non small cell lung cancer were randomly divided into two groups.Each group has 30 cases.Results Response rates of EP regimen and CAP regimen were 38 8% and 33 3% respectively.There was no statistical significant difference between them ( P >0 05).Gastrointestinal tract reaction and epilation reaction of CAP regimen were more serious than that of EP regimen( P <0 05).Mylos suppression had no statistical difference between two regimens.Conclusion Both EP regimen an CAP regimen can be used as first line regimens for treatment of non small cell lung cancer of older patient.The EP regimen is regarded as a better,convenient and tolerable regimen.