手足口病患儿肠道病毒71感染相关免疫功能变化及其临床意义

Immune Function Changes of Children With Hand-Foot-Mouth Disease Caused by Enterovirus 71 Infection and Its Clinical Significance

手足口病(HFMD)患儿肠道病毒71(EV71)感染可导致中枢神经、呼吸系统损害,引发脑炎、急性弛缓性麻痹、脑水肿和心肌炎等,个别重型HFMD患儿病情进展快,易致死亡。HFMD发病机制可能与病毒感染所致免疫功能异常有关,尤其是细胞免疫功能低下。此外,EV71病毒感染导致的全身炎症反应综合征(SIRS)也可能参与HFMD的发病。因此早期对HFMD患儿进行细胞免疫支持治疗,并阻断SIRS发展,对改善预后意义重大。

Children with hand-foot-mouth disease （HFMD） which caused by enterovirus 71 （EV71） can appear central nervous and respiratory system damage. Meanwhile, EV71 can cause encephalitis, brain edema and myocarditis. Some severe cases are prone to death. The pathogenesis of HFMD is likely related to immune disorders caused by EV71 infection. Additional, systemic inflammatory response syndrome （SIRS） may play an important role in attack. As a result, it is necessary for us to take cellular immune support treatment in time and block SIRS development. It is also significant for children with HFMD to improve the prognosis.