摘要
目的探讨原发性高血压人群血压展峰现象与颈动脉内膜中层厚度(CCA—IMT)、颈动脉斑块以及肱一踝动脉脉搏波速度(baPWV)的相关性。方法对入选的原发性高血压患者128例进行24h动态血压监测,根据结果分为展峰组49例和非展峰组79例,两组均进行颈动脉超声检查,测量CCA—IMT和颈动脉斑块,同时进行baPWV检测,比较两组CCA—IMT、颈动脉斑块以及baPWV的差异。结果展峰组的CCA—IMT(1.12±0.21)mm、斑块检出率87.76%、斑块的平均厚度(1.35±0.33)mm、baPWV(1629.9±223.5)cm/s,均高于非展峰组[(0.97土0.34)mm、68.35%、(1.21±0.24)mm、(1507.6s±247.6)cm/s](P〈0.05或0.01)。多元Logistic逐步回归分析结果显示,仅血压晨峰为CCA—IMT及baPWV值增大的独立危险因素,OR值及95%C1分别为:1173(0.97~428)和2.26(1.84~6.78)(均P〈0.01)。结论血压晨峰可能与动脉粥样硬化和动脉弹性功能减退有关。
Objective To investigate the relationship of morning blood pressure surge with carotid intima-media thick- ness (CCA-IMT), carotid arteries plaque,brachial-ankle pulse wave velocity (baPWV) in patients with essential hypertension. Methods According to the results of 24 h ambulatory blood pressure monitoring, 128 patients were classified as the morning BP surge (MBPS group, n=49) or non-morning BP surge (NMBPS group, n=79). Patients underwent carotid ultrasonography, CCA-IMT and plaques were examined and the baPWV were also measured. Results In the MBPS group,the CCA-IMT [(1.12 ± 0.21) mm vs (0.97 ± 0.34)mm], the detection rate of plaques (43/49 vs 54/79 ), the average thickness of carotid arteries plaque [(1.35 ±0.33)mm vs (1.21 ±0.24)mm], the baPWV [(1629.9 ± 223.5)cm/s vs (1507.6 ± 247.6)cm/s] were higher than those in NMBPS group (P〈0.05 or 0.01). Multivariate logistic regression analysis showed that MBPS was independent risk factor of increased CCA-IMT (OR=1.73, 95%C1: 0.97-4.28) and baPWV (OR=2.26, 95%C1:1.84-6.78, P〈0.01). Conclusion Morning blood pressure surge in patients with essential hypertension is associated with carotid atherosclerosis and damage of aortic elasticity.
出处
《浙江医学》
CAS
2012年第13期1132-1135,共4页
Zhejiang Medical Journal
关键词
血压晨峰颈动脉硬化动脉僵硬度脉搏波传导速度原发性高血压
Morning blood pressure surge Carotid atherosclerosis Arterial stiffness Brachial-ankle pulse wave velocity Essential hypertension