光学相干断层扫描仪检测正视眼与高度近视眼中央角膜厚度差异的研究

Measurement of central corneal thickness in subjects of emmetropia and high myopia with optical coherence tomography

目的探讨光学相干断层扫描仪OCT测量正视眼与高度近视眼中央角膜厚度（CCT）是否存在差异。方法高度近视患者等效球镜SE≥-6．00D。散光≤-3．00D。共82例164眼，正视眼组裸眼视力≥1．0，屈光度为＋1．000—-0．25D，散光≤-050D，共48例96眼。用光学相干断层扫描仪（OCT-3）测量中央角膜厚度（CCT）。结果高度近视组164眼CCT为470．67～630．47（534．03±40．66）um，正视组96眼CCT446．00～653．28（538．44土40．75）um，两者差异无统计学意义（t=0．842，P=0．401）。双眼CCT比较右眼OCT为（534．64±40．52lum，左眼CCT为（535．68±40．981um，两者无统计学差异（P〉0．05）。高度近视组CCT与屈光度两者无明显相关（P〉0．05）。结论高度近视眼CCT较正视眼无明显变化，近视形成发展的过程对角膜中央未形成明显影响。

Objective To examine the central corneal thickness （CCT） in subjects with emmetropia and high myopia. Methods CCT was measured by OCT3 in 82 high myopes （〉-6 D in spherical equivalent refraction, 〈-3.00D in astigmatism ） and 48 emmetropic subjects （＋ 1.00D to -0.25D,a maximum of -0.50 D astigmatism were accepted.）. The results were exam- ined by t-test and Pearson correlation analysis. Results The average CCT for the myopic and emmetropic groups was （534.03 ±40.66） μm （470.67 ± 630.47μm） and （538.44 ± 40.75）μ m （446.00 - 653.28μ m）, respectively （P 〉 0.05）. the CCT val- ues of right and left eyes were （534.64 ± 40.52） μ m and （535.68 ± 40.98）μm, respectively（P 〉0.05 ）. CCT was not correlated with SE in myopes （P 〉0.05）. Conclusion There are no differences in central corneal thickness between subjects with emmetropia and high myopia, which suggests that the process of myopia progresses does not influence the central cornea.