家族性多原发癌3例临床分析

Reports and Analysis of 3 Multiple Primary Cancers Cases from a Family

目的分析多原发癌(MPC)在家族遗传方面的因素,以提高对多原发癌的诊治及预防。方法结合国内外相关文献,对一家族(无近亲结婚)三代中癌症患者的临床资料进行分析。结果该家族三代中7例为癌症患者,男性2例,女性5例,年龄39～78岁,平均55岁,其中3例女性发生异时性MPC,每次相隔3～5年。大肠癌4例(57%);子宫癌5例(71%);膀胱癌、肺癌各1例(14%)。该家族中MPC患者占总家族患癌成员的43%(3/7)。结论该家族中MPC患者5年生存率较各单发恶性肿瘤者高。了解患者的家族病史,早期诊断,可显著延长患者生存期。

Objective To analyze the genetic factors of multiple primary cancers so as to improve the diagnosis and prevention of multiple primary cancers.Methods Clinical data from a family with multiple primary cancers were analyzed,and the related literatures were reviewed.Results The family had a total of 7 cancer sufferers,including 2 males and 5 females.The age was from 39 to 78 years,with an average 55 years old.Three women had metachronous MPC,with an intervals of 3 to 5 years.There were 4（57%） colorectal cancer,5（71%） uterine cancer,1（14%） bladder cancer and 1 lung cancer.3 of the 7（43%） cancer suffers had MPC.Conclusion The five-year survival in patients with MPC is higher than that in patients with a single type of cancer.Understanding the patient＇s family and medical history,early diagnosis and active treatment can significantly improve survival.