检测系统性红斑狼疮病人血浆可溶性血栓调节蛋白的临床意义──附46例报告

Clinical significance of plasma soluble thrombomodulin in 46 patients with systemic lupus erythematosus．

目的：探讨检测系统性红斑狼疮(SLE)病人血浆可溶性血栓调节蛋白(sTM)的临床意义。方法：应用酶联免疫吸附法(ELISA)测定46例SLE病人和20名正常人血浆sTM水平，分析sTM与SLE活动期疾病活动度的关系。结果：SLE活动期组sTM水平高于非活动期组和对照组(P ＜0．01)。sTM与多个SLE疾病活动度评分相关，与低补体C3血症、抗双链脱氧核糖核酸（dsDNA）抗体滴度水平相关(P ＜0．05)。高水平sTM与狼疮肾炎、浆膜炎相关(P ＜0．01)。结论：血浆sTM水平与SLE活动期和疾病活动度有较好的相关性，可作为判断SLE疾病活动性的指标。

 Objective: To determine the clinical significance of plasma soluble thrombomodulin(sTM) in patients with SLE． Method: The plasma sTM level of 46 SLE patients and 20 healthy controls was measured with enzyme-linked immunosorbent assay(ELISA)． Results: The sTM levels were significantly higher in SLE patients with active disease than in those with inactive disease and healthy controls (P ＜0．01)． The sTM levels in SLE patients correlated with the levels of C3 and titers of anti-dsDNA antibodies(P ＜0．05) and it correlated closely with three SLE disease activity indexes ． The sTM levels were significantly high in patients with lupus nephritis and serositis(P ＜0．05)． Conclusion: The plasma sTM level of SLE is correlated well with disease activity it can be a useful parameter to determine the activity of SLE． 