血清GGT、ALP及ADA在肝癌诊断中的临床价值

Clinical Value of the Detection of Serum GGT,ALP and ADA in the Diagnosis of Liver Cancer

目的探讨血清R-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)和腺苷脱氨酶(ADA)检测对肝癌诊疗的临床意义。方法随机选取肝癌患者、良性肝病患者及健康体检者(正常对照组)各45例,分别检测其血清GGT、ALP及ADA含量,统计分析各组间结果差异,并比较三种指标单独或联合检测对肝癌诊断的敏感性和特异性。结果血清GGT、ALP及ADA含量在肝癌患者组明显高于良性肝病患者组及正常对照组,差异有统计学意义(P<0.05);对肝癌的诊断:单项检测GGT、ALP及ADA的敏感性分别为84%、69%、78%,特异性分别为76%、89%、91%;三项联合检测的敏感性为91%,特异性为69%。结论三项联合检测提高了对肝癌诊断的敏感性,有利于肝癌的早期诊断,降低了对肝癌的漏诊率。

Objective To investigate clinical value of serum GGT,ALP and ADA in the diagnosis of liver cancer.Method The levels of serum GGT,ALP and ADA were detected in 45 cases of liver cancer,45 cases of benign liver disease and 45 cases of normal controls,and the differences were analyzed between the three groups.The sensitivity and specificity of the three indicators（alone or combined） were also evaluated in the diagnosis of liver cancer.Result The level of serum GGT,ALP and ADA in liver cancer group were significant higher than that in the benign liver disease group and normal controls（P0.05）.The detection sensitivity of GGT,ALP and ADA in liver cancer diagnosis were 84%,69%,78%,and the specificity were 76%,89%,91% separately.The sensitivity and specificity of joint detection of GGT,ALP and ADA were 91% and 69% respectively.Conclusion The combined detection of three indicators improved the diagnostic sensitivity,which will be conducive to improving the early diagnosis and reducing the misdiagnosis of liver cancer.