复方甘草酸苷治疗慢性乙型肝炎抗肝纤维化的疗效研究

The Treatment Outcome of Compound Glycyrrhizin on Chronic Type B Hepatitis

目的观察复方甘草酸苷治疗慢性乙型肝炎抗肝纤维化的疗效。方法将62例慢性乙型肝炎患者随机分为两组,A组34例为治疗组,给予复方甘草酸苷,1次/d;B组28例为对照组,予还原型谷胱甘肽(古拉定)治疗,1次/d,两组均治疗1个月。观察治疗前后两组肝功能,血清透明质酸(HA)、层粘连蛋白(LN)、IV型胶原(IV-C)及HBV-DNA的变化。结果治疗组对降低肝纤维化指标方面明显优于对照组(P<0.01),但在改善肝功能,抑制乙型肝炎病毒方面无显著差异。结论应用复方甘草酸苷可以早期预防和阻止慢性乙型肝炎向肝硬化发展。

Objective To observe the changes of hepatic fibrosis indexes of chronic type B hepatitis which treated by Compound Glycyrrhizin. Methods 62 patients of chronic type B hepatitis randomly divided into two groups, A group is treat- ment group, treated by Compound Glycyrrhizin once a day, B group is control group, treated by Reduced Glutathione once a day. One month later after treatment, observed the changes of liver function, serum hyaluronic acid （HA）, laminin （LN）, IV type collagen （ IV - C） and HBV DNA of the two groups. Results Values of hepatic fibrosis indexes in treatment group de- creased more significantly than those in control group （P 〈0. 01 ）, but there is no difference in improving liver function and in in- hibiting copy of hepatitis B virus. Conclusion Treatment by Compound Glycyrrhizin can prevent and stop the development of chronic type B hepatitis to hepatic cirrhosis in earlier period.