尿蛋白系列与老年原发性高血压病

A SERIES OF PROTEINS IN URINE AND HYPERPIETICS IN OLD FOLKS

目的：探讨老年人血压的昼夜间的变化和与尿系列蛋白的关系，以寻找高血压早期肾损害的诊断指标。方法：应用动态血压监测（ABPM），和用ELISA法及我室自己改良的免疫比浊法．测定尿转铁蛋白（Tf）、微量白蛋白（Alb）、免疫球蛋白（IgG）、N－乙酰－β－D氨基葡萄糖苷酶（NAG）及视黄醇结合蛋白（RBP），对120例老年原发性高血压病患者进行了观察比较.结果：120例高血压病患者ABMP后发现有57例（47．5％）血压昼夜节律正常（A组），63例（52．5％）血压昼夜节律异常（B组）。两组高血压患者的尿系列蛋白比较均有显著差异。结论：老年高血压早期除了血压水平升高外．还有相当一部分患者存在着较严重的节律紊乱．血压昼夜节律异常组的尿Tf．Alb，IgG，NAGRBP明显高于血厌昼夜节律正常组。

Objective: To discuss the relationship between the variety about hyperpietics in old folks in 24 hours and a series of proteins in urine, as a result boking for the diagnoses parameters of forepart renal damage in hypertension. Methods: To observe and compare the blood pressure for 120 cases hyperpietics in old folks by ABPM and to mensurate transferrin protein, albumin, IgG, NAG. retinol-binding protein by ELIASA and our method which is a improved immune nephelometer. Results: After examining the blood pressure by ABPM. 57 cases were normal blood pressure rhythm (A group, 47. 5 % ). 63 cases were abnormal blood pressure rhythm (B group, 52. 5 % ).There was a remarkable difference for a series of proteins in urine between A group and B group. Conclusions: The forepart hyperpietics in old folks not only blood pressure are elevated but also serious abnormal blood pressure rhythm,the quantity of Tf, Alb, IgG, NAG. RBP in urine higher than A group (normal blood pressure rhythm).