先天性胆管扩张症胆囊粘膜增殖性变化

Mucosal proliferative changes of gallbladder in congenital biliary dilatation

目的 观察先天性胆管扩张症胆囊粘膜的增殖性变化。方法 先天性胆管扩张症患者42例 ,其中儿童 35例 ,成人 7例 ;慢性胆囊炎胆石症成人 2 0例 ,对照组 5例。取石蜡切片行HE和增殖细胞核抗原 (PCNA)染色 ,观测增生形态指标 (即胆囊粘膜皱襞高度、皱襞密度、皱襞细胞密度 )以及PCNA阳性率。结果 胆管扩张症、慢性胆囊炎胆石症患者的增生形态指标及PCNA阳性率均高于对照组 (P <0 .0 5 )。成人胆管扩张症PCNA阳性率高于慢性胆囊炎胆石症 (P <0 .0 5 )。结论 先天性胆管扩张症自幼即存在胆囊粘膜增殖性增高现象 ,成人病例且高于慢性胆囊炎胆石症。

Objective To observe the mucosal proliferative changes of gallbladder in congenital biliary dilatation (CBD). Methods The gallbladder specimens from 42 cases of CBD (35 children, 7 adults) and 20 adults of chronic cholecystitis (CC) and cholecystolithiasis were examined by HE and PCNA staining for hyperplastic changes (height, density and cell density of mucosal folds) and positive PCNA rate. Five children selected as control. Results As compared with the controls, all the gallbladders from CBD and CC showed mucosal hyperplastic changes and higher positive PCNA rates. The gallbladders from adult CBD also had higher positive PCNA rates than that of CC. Conclusion Patients with CBD have increased proliferative activity of the gallbladder mucosa which is higher than that of CC .