肠神经元性发育不良的病理形态学研究

Investigation on the pathological morphology of intestinal neuronal dysplasia

目的 探讨常规组织切片中肠神经元性发育不良的病理形态学特征。方法 送检 48例HD及HD类缘病肠段采取定长度纵行全层取材 ,常规制片 ;观察肠神经元及神经节细胞形态和数量的变化并与正常组进行比较。结果 肠神经元性发育不良 (B型 )肠壁肌间神经节细胞数明显增多 ,神经节细胞密度增高 ,81.2 5 %的病例可见巨神经丛 ,5 0 %的病例可见孤立或异位神经节细胞。结论 巨神经丛、孤立和异位神经节细胞、肠壁神经节细胞数目增多是IND(B型 )的重要特征。

Objective To investigate the pathological characteristics of intestinal neuronal dysplasia type B ( IND(B))on conventional histological sections. Methods The morphology and number of plexus and ganglion cell of the resected specimens from 48 cases with Hirschsprung's disease (HD) and allied HD were studied. The specimen were resected by the longitudinal, whole layer, same length, and compared with the normal controls. Results In IND (B) cases, the numbers of ganglion cell were increased in myenteric plexuses.The giant ganglia ( 81.25 %) and isolated ganglion cell (50%) were observed. Conclusion The appearance of giant ganglia and isolated ganglion cell, increasing in ganglion cell density are important fefatures of IND (B) .