中心静脉导管引流联合白细胞介素-2注射治疗肝性胸水患者21例疗效观察

Curative effect of central venous catheter in interleukin-2-treated patients with hepatic hydrothorax

目的观察中心静脉导管引流联合白细胞介素-2(IL-2)注射治疗肝性胸水的疗效。方法 40例肝性胸水患者随机分成治疗组(21例)和对照组(19例),两组患者均给予护肝、输白蛋白等支持治疗的基础上,对照组采用常规穿刺抽胸水治疗,治疗组则采用中心静脉导管留置胸腔引流管,完全排空胸水后,注入IL-2,观察两组患者的疗效及并发症情况。结果治疗组治疗总有效率为85.7%,对照组治疗总有效率为52.6%。两组比较差异有统计学意义(P<0.05);治疗组的胸水消退的天数、平均住院费用以及住院天数均明显缩短(P<0.05),并发症少。结论中心静脉导管联合IL-2治疗肝性胸水的疗效显著,值得临床推广。

Objective To observe the curative effect of central venous catheter when combined with interleukin （IL） - 2 treatment for he- patic hydrothorax. Methods Thirty - three patients with hepatic hydrothorax were randomly assigned to an experimental treatment group （ n = 17 ） or a control treatment group （n = 16）. The experimental group received pleural effusion with continuous drainage by central venous catheter, while the control group was relieved of pleural effusion by conventional puncture. Both groups were administered IL - 2 injection into the thoracic cavity after evacuation of pleural effusion. All patients were administered post - operative therapy, including albumin, to protect the liver. The curative effect and complications of two groups wet ~ observed. Results The central venous catheter group had a sig- nificantly better total effective rate than the conventional puncture control group （82.4% vs 56.3% ; P 〈 0.05 ）. The central venous cathe- ter group also had significantly lower duration of pleural effusion persistence, average hospitalization expenses, and duration of hospital stay （ P 〈 0.05 ） , as well as experiencing fewer complications. Conclusion The central venous catheter method for IL - 2 intrathoracic treat- ment produces a good therapeutic effect in patients with hepatic hydrothorax.