CRT前后血清MMP-2、9和NT-pro-BNP水平及意义被引量：1

The levels and meaning of serum N-terminal pro-brain natriuretic peptide and matrix metalloproteinase-2,9 in preoperative and postoperative cardiac resynchronization therapy

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摘要回顾性分析我院行心脏再同步化治疗(CRT)前后心力衰竭患者血清N端脑钠肽(NT-pro-BNP)、基质金属蛋白酶2、9(MMP-2、9)水平变化对评价CRT疗效的可行性。采用酶联免疫法(ELISA)检测血清MMP-2、9和NT-pro-BNP水平。结果表明,CRT组术后3、6个月血清MMP-2、9和NT-pro-BNP水平显著低于术前及对照组(P<0.05)。血清MMP-2、9和NT-pro-BNP可以作为评价CRT疗效的生化指标。 To analyse the feasibility that serum NT-pro-BNP and matrix metalloproteinase -2,9 concentration changes to curative effect evaluation preoperative and postoperative cardiac resynchronization therapy. Serum NT-pro- BNP, MMP- 2,9 were detected with ELISA. This results showed that the third and sixth months after CRT, serum NT-pro-BNP, MMP-2,9 were significantly lower than those of the preoperative and control group （ P 〈 0.05 ）. Therefore, serum NT-pro-BNP, MMP-2,9 can serve as indicators to evaluate the effectiveness of CRT.

作者李镇徐健苏浩程久佩邵名亮方存明

机构地区安徽医科大学附属省立医院心血管内科安徽省宣城市人民医院心血管内科

出处《安徽医科大学学报》 CAS 北大核心 2012年第9期1134-1136,共3页 Acta Universitatis Medicinalis Anhui

关键词心脏再同步化治疗 N端脑钠肽基质金属蛋白酶2、 9 cardiac resynchronization therapy N-terminal fragment of the pro-peptide of brain natriuretic peptide matrix metalloproteinases 2,9

分类号 R541.61 [医药卫生—心血管疾病]

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