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c-myc基因扩增与HPV感染在宫颈病变中的关系 被引量：3

The relationship between HPV infection and c-myc gene in cervical lesions
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摘要 分别以HC-Ⅱ法及荧光原位杂交(FISH)法检测109例不同级别宫颈病变患者宫颈脱落细胞中高危型人乳头瘤病毒(HPV)感染情况及c-myc基因扩增情况,结果显示宫颈脱落细胞中c-myc基因的扩增率、高危型HPV的感染率与宫颈病变程度密切相关,高危型HPV感染和c-myc基因扩增在宫颈癌的发生发展中可能起着协同作用。 The amplification of c-myc gene and HR-HPV infection in 109 cases cervical cast-off cell specimens of cervical lesion were detected by fluorescence in situ hybridization （FISH） and hybrid capture II （ HC- II ）. There was a close correlation between HR-HPV infection rate, c-myc gene amplification rate and cervical lesion degree. High-risk HPV infection and c-myc gene amplification may play a synergistic role in the development of cervical cancer.
作者 丁玉兰 赵卫东 冯定庆 朱园园 金夏 宣恒华 周虎 桂云
机构地区 安徽医科大学附属省立医院妇产科分子实验室
出处 《安徽医科大学学报》 CAS 北大核心 2012年第9期1139-1141,共3页 Acta Universitatis Medicinalis Anhui
关键词 高危型HPV c—myc基因 荧光原位杂交 宫颈癌 宫颈上皮内瘤变 high-risk human papilloma virus c-myc gene fluorescence in situ hybridization cervical cancer cervical intraepithelial neoplasia
分类号 R737.33 [医药卫生—肿瘤] R73-34 [医药卫生—肿瘤]
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参考文献7

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同被引文献31

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引证文献3

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安徽医科大学学报
2012年 第9期

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