维生素C拮抗氟致大鼠雄性生殖损害的初步研究

The Primary Study of Antagonism of Selenium on Fluoride Induced Reproductive Toxicity of Male Rat

探讨在饮水中加入 1 0mg/ml的维生素C时对氟染毒大鼠雄性生殖系统损害的影响。结果表明 ,实验剂量的维生素C对雄性大鼠饮用 15 0mg氟化钠 /L饮水所导致的附睾精子总数减少、血清和睾丸组织中LPO含量升高、附睾ATP酶活性抑制等损害作用具有明显的拮抗作用 ,与饮水中加入2 0mg亚硒酸钠 /L的拮抗效果类似。但不能显著改善睾丸和附睾组织中谷胱甘肽过氧化物酶的活性。

The protective effect of ascorbic acid at dose level of 1.0mg/L in drinking water against the fluoride induced damage on reproductive system of rat was studied.150mg/L sodium fluoride (NaF) in drinking water of male rat can cause the significant decrease of sperm count and mobility,the increase of serum and testicular lipid peroxides (LPO) contents,and the adenosine triphosphatase (ATPase) activity depression of epididymis.All of those effects are reversible by adding adequate ascorbic acid in drinking water simultaneously.The effects of ascorbic acid against fluoride induced damages are similar to those produced by 2.0mg/L Na\-2SeO\-3 in the drinking water of rats.However,no significant recovery of fluoride induced effects on GSH Px activities in the tissues of testis and epididymis were observed in ascorbic acid and fluoride group.The mechanism of ascorbic acid on fluoride induced damage of male reproducttve system need to be further studied.