冠心病患者胰岛素抵抗危险因素的病例-病例研究

A Case-case Study on Risk Factors of Insulin Resistance in Coronary Heart Disease Patients

以病例—病例研究设计对 118例临床确诊的冠心病(CHD)患者和 5 3例血管痉挛性CHD(X综合征 )患者的胰岛素抵抗 (IR)和相关危险因素的关系进行了调查和分析。 88例胰岛素敏感性指数≤ 2 5 %百分位点和 /或胰岛素水平≥ 75 %百分位点纳入IR组 ,其它 83例纳入非IR组。单因素分析显示 :吸烟和超重或肥胖的优势比 (OR)分别为 2 2 9(1 0 6～ 4 98)和1 89(0 98～ 3 36 ) ,其它因素无明显统计学联系 :计量资料的均数比较显示 :IR组的体重指数和每日吸烟量显著高于非IR组 :多因素Logistic回归显示 :被筛选进入回归方程的变量为体重指数和吸烟史。上述结果提示 。

In order to investigate the relationship between insulin resistance(IR) and risk factors of coronary heart disease(CHD), a case-case study was conducted. There were 48 acute myocardial infarction patients, 70 coronary angiographycally defined CHD and 53 vasospastic angina being brought into the study. Among them, 88 insulin sensitive index ≤P\-\{25\} and/or serum insulin lever≥P\-\{75\} were defined as insulin resistance group, other 83 were defined as non-insulin resistance group.Uni-variable analysis indicated that cigarette smoking and overweight were associated with IR with Odds Ratio of 2.29 (1 .06～4.98) and 1 89(0 98～ 3 36 ) respectively Means comparison showed that body mass index (BMI) and numbers of cigarette consumption per-day in IR group were significantly higher than that of non-IR group. Logistic regression analysis indicated that BMI and cigarette smoking being selected into equation. It seems that cigarette smoking and overweight associated with IR in CHD patients.