互聚物复合形成对口腔粘膜粘附片释放的影响(英文)

The Effect of Interpolymer Complex Formation on the Release of Buccoadhesive Tablets

通过测量 HPMC和 Carbopol974 P在不同 p H值的缓冲液中的混合溶液浊度变化的方法证实了互聚物复合形成。复合的程度在酸性 p H条件下高 ,当两者比例为 1∶ 1时最强 ,然后随着 p H值的升高而减弱。以非洛地平为模型药物 ,采用直接压片工艺制备了口腔粘膜粘附片。体外释放实验表明 ,互聚物复合形成对药物的释放有很大影响 ,能够有效控制药物释放。粘附片中加入不同酸碱度的物质可调节药物的释放速率。聚合物间的这种特殊的互聚物复合形成现象可用于设计具有不同释药行为的药物释放系统。

Interpolymer complex formation between hydropropylmethylcellulose(HPMC) and carbopol974P was examined by turbidity measurement. The degree of complexation was studied as a function of pH, and the degree is higher at lower pH. The maximum complexation was found at a polymer ratio of 1∶1 at pH 1.8 and 3.0, and then decreases with an increase in pH value. Further release studies \%in vitro\% show that interpolymer complex formation has great effect on the release behavior of buccoadhesive tablets made by direct compression technology and can control the release rate of drug. The release behavior can also be regulated by the addition of substances with different acidity. This specific property of interpolymer complexation may be utilized to design drug delivery systems of various release behaviors.