树突细胞在类风湿性关节炎病理机制中的免疫原性和耐受性双重作用

Dual role of dendritic cells in the pathological mechanism of rheumatoid arthritis: immunogenicity and tolerogenicity

树突细胞(dendritic cells,DCs)是体内功能最强大的专职抗原提呈细胞(antigen-presenting cell,APC),具有免疫原性和耐受性双重作用。DCs的免疫原性体现在作为专职APC对自身抗原异常提呈,引起机体免疫系统紊乱,是参与类风湿关节炎(rheumatoid arthritis,RA)发生的一个重要原因;DCs的耐受性则体现在通过多种机制诱导抗原特异性T细胞消除、无能及调节性T细胞(regulatory T cells,Tregs)的产生,导致免疫耐受,发挥对RA的调控作用。该文结合该课题组的研究结果对DCs参与RA的发病机制以及在RA病理机制中的调控作用方面进行介绍和评论。

Dendritic cells （DCs） are the most powerful professional antigen presenting cell （APC） , which have immunogenic and tolerogenic function in immune system. As a professional APC, the immunogenic DC presents self-antigen abnormally and results in immune system disorder. The immunogenie function may be one pathogenesis of RA. On the other hand, the tolerogenicity of DC could induce antigen specific T cell deletion, an-ergy and produce regulatory T cells （Tregs）, which make DCs play a regulatory role in RA. This paper makes an introduction about how DCs are involved and play a regulatory role in the pathogenesis of RA.