辛伐他汀对自发性高血压大鼠血管功能作用研究

Effects of chronic treatment with simvastatin on vascular function in spontaneously hypertensive rats

目的观察口服20 mg.kg-1辛伐他汀对自发性高血压大鼠血压与血管功能作用。方法观察辛伐他汀口服7周高血压大鼠血压、血管反应性、NO2-/NO3-水平以及血管组织学变化。结果治疗7周后,各组大鼠体重、心率无显著性差别(P>0.05),辛伐他汀长期给药不能明显降低高血压大鼠收缩压(P>0.05)。大鼠血管对乙酰胆碱反应性明显改善(P<0.05),而对硝普钠反应性无明显变化(P>0.05);与对照组比较,辛伐他汀明显升高血清NO2-/NO3-水平,并能明显减少血管壁弹性膜层数以及中膜厚度(P<0.05)。结论辛伐他汀对自发性高血压大鼠有血管扩张作用以及改善血管重构等作用。但不能抑制自发性高血压大鼠血压的升高。

Aim To study the effects of chronic treatment with 20 mg · kg^-1 simvastatin oral administration on blood pressure and vascular function in spontaneously hypertensive rats. Methods The effects of simvastatin were investigated by determination of the level of blood pressure, vascular reactivity, NO2^-/NO3^- and histological change of aorta. Results In all groups, HR and BW showed no difference compared with vehicle-treated group （P 〉 0. 05 ）. Long-term administration with simvastatin （20 mg· kg^-1 ） had no significant effects on systolic blood pressure （ P 〉 0. 05 ）. In SHRs, simvastatin enhanced the aortic relaxation toacetylcholine after 49 d treatment （ P 〈 0.05 ）, but it had no significant effect on the relaxation to sodium nitroprusside （ P 〉 0. 05 ）. Oral administration of simvastatin significantly increased the serum level of NO2^-/ NO3^- compared to the control group （P 〈 0.05 ）. In addition, simvastatin showed significant reduction in te elastin bands and media thickness in rat aorta （P 〈 0. 05）. Conslusion Chronic treatment with simvasta- tin expects no antihypertensive effect on SHRs, despite its vasorelaxant action and anti-remolding properties.