神经营养素在椎间盘源性腰痛机制中的作用研究进展

Reasearch on mechanism of neurotrophins in discogenic low back pain

椎间盘源性腰痛是慢性腰痛常见的类型,然而,其疼痛机制尚不明确。越来越多的证据表明,神经营养素在椎间盘源性腰痛机制中具有重要地位。本文从神经营养素在椎间盘、脊根神经节和脊髓后角等疼痛传递通路中的作用,对其在椎间盘源性腰痛机制中的研究进展进行综述。通过调控神经营养素及其受体来改变疼痛信息传递,为椎间盘源性腰痛的治疗提供新思路。

Discogenic low back pain is the common type of chronic low back pain. However,its mechanism has not been completely clarified. Considerable evidence shows that neurotrophins play an important role in discogenic low back pain. The paper summarizes the mechanism of neurotrophins on discogenic low back pain according to the pain transfer pathway of neu- rotrophins in intervertebral disc, dorsal horn ganglia and spinal trigeminal nucleus. Changing the pain transmission by regulat- ing neurotrophins and its receptor will provide a new way for the treatment of discogenic low back pain.