老年急性胰腺炎患者血清NO,TNF-α的变化及临床意义

Measurement of serum NO and TNF-α in elderly parients with acute pancreatitis and their clinical significance

目的 探讨老年急性胰腺炎 (AP)患者血清一氧化氮 (NO)和肿瘤坏死因子α(TNF α)的变化及临床意义。方法 对 32例老年AP患者及 2 0例健康老年人血清中NO和TNF α水平进行检测。结果 老年AP患者血清中NO浓度明显低于正常对照组 ,且随病情加重降低更为明显 (P <0 0 1 ) ;而血清TNF α浓度明显高于正常对照组 ,且随病情加重升高更为明显 (P <0 0 1 ) ,NO和TNF α呈显著负相关 (P <0 0 5)。结论 NO及TNF α是参与老年AP发生发展的重要因素之一 。

Objective To study the clinical significance of changes in serum NO and TNF α levels in elderly patients with acute pancreatitis(AP).Methods The serum concentration of NO,TNF α were determined in 32 elderly patients with AP and 20 healthy elderly people.Results The results showed that the serum NO levels was significantly lower,while the level of TNF α was markedly higher in elderly patients with AP than those of control( P <0 05),and these changes were most obvious in severe AP.The analysis of liner correlation showed the level of serum NO was negatively correlated with that of seuum TNF α( P <0 05).Conclusions The results suggest that NO and TNF α play an important role in the pathophysiology of AP and were usefull in evaluating the severity of AP.