舌鳞状细胞癌组织中p^(53)、p^(21)和bcl-2基因蛋白的表达

Expression of p^(53), p^(21) and bcl-2 Proteins in Tongue Squamous Cell Carcinoma

【目的】研究 p5 3、p2 1和bcl 2基因蛋白在舌鳞状细胞癌组织中的表达及其临床意义。【方法】用免疫组化SP法检测 5 4例舌鳞状细胞癌组织标本p5 3、p2 1和bcl 2癌基因蛋白表达。【结果】舌鳞状细胞癌组织中p5 3、p2 1和bcl 2蛋白阳性率分别为 46 %、6 1%、46 % ;p5 3和 p2 1蛋白表达与肿瘤细胞分化程度及颈淋巴结转移有关 (P <0 0 5 ) ;p5 3蛋白表达与 p2 1蛋白表达有关 (P <0 0 5 ) ,bcl 2基因蛋白表达与 p5 3或p2 1基因蛋白表达无关 (P >0 0 5 )。【结论】舌鳞状细胞癌组织中具有较高的 p5 3、p2 1和bcl 2癌基因蛋白表达 ;p5 3和 /或p2 1蛋白阳性病例恶性程度高 ,易发生颈淋巴结转移。p5 3和 /或 p2

Objective To study the expression of p53, p21 and bcl 2 proteins in tongue squamous cell carcinomas (SCC) and their significances. Methods The expression of p53, p21 and bcl 2 proteins in 54 cases of tongue SCC was detected by immunohistochemical SP method. Results The positive expression of p53, p21 and bcl 2 proteins in tongue SCC were 46%, 61%, 46%, respectively.The expression of p53 and p21 proteins were related with tumor pathological grade (P<0 05)and cervical lymph node metastasis. The expression of p21 protein was associated with that of p53 protein (P<0 05). There was no significant relation among the expression of the three proteins. Conclusion p53, p21 and bcl 2 proteins can extensively positive express in tongue SCC. The expression of p53 and/or p21 proteins is valuable in determining the tumor biological behavior, metastasis potential and prognosis.