70例非综合征性唇腭裂环境暴露因素分析

70 cases of nonsyndromic cleft lip and palate environmental risk factors analysis

目的:探讨非综合征性唇腭裂发病的孕前及早孕期的环境危险因素,为降低非综合征性唇腭裂的发生率提供理论依据。方法:经B超确诊为唇腭裂的胎儿及部分因唇腭裂手术的患儿70例,以其父母为对象作为病例组,选择同期出生未患唇腭裂的父母(共70例)作为对照组。对病例组及对照组进行问卷调查,对结果进行x2检验作单因素分析,用Logistic回归作多因素分析。结果:单因素x2检验发现唇腭裂发生的孕前和孕早期环境危险因素有:有毒物质接触、孕期患病、孕期用药、被动吸烟、未服用叶酸、母亲文化低,其中有毒物质接触、孕期患病、未服用叶酸3个相关因素进入Logistic回归模型。结论:有毒物质接触、孕期患病、未服用叶酸可能是本地区发生先天性唇腭裂的主要环境危险因素。

Objective：To analysis environmental risk factors of nonsyndromic cleft lip and palate before pregnancy and in early pregnancy, then to help reducing nonsyndromic cleft lip and palate incidence. Methods：Firstly, we collected 70 cases cleft lip and palate （including some fetus diagnosis by B ultrasound and some children need to do operation for cleft lip and palate） , their parents were divided into the test group ; Secondly, we selected 70 cases without cleft lip and palate in the same period as the control group. Two groups carried out a questionnaire survey. Then we using x2 test for single factor analysis, using Logistic Regression for analysis of multiple factors. Results： The single factor x2 test found that risk factors are exposure to toxic substances during pregnancy, illness, medications during pregnancy,passive smoking,without taking folie acid ,the mother low degree, in which exposure to toxic substances ,illness ,not taking folio acid entered into the Logistic Regression model. Conclusions： Exposure to toxic substances ,illness,not taking folio acid may be the occurrence of congenital nonsyndromic cleft lip and palate of the major environmental risk factors in this area.