两种剂量丙种球蛋白治疗新生儿溶血病的疗效分析

The Therapeutic Effects of Two Doses of Gammaglobulin for neonatal hemolytic disease

目的:观察两种剂量丙种球蛋白(IVIG)治疗新生儿ABO溶血病(ABO HDN)的临床疗效。方法:将ABO HDN患儿随机分成两组,对照组给予IVIG 0.5 g/(kg·d),连用3天,治疗组给予IVIG 1 g/(kg·d),连用2天。观察两组黄疸消退时间,治疗后24小时、72小时血胆红素值。结果:两组相比较,治疗组黄疸消退时间短,治疗后24小时、72小时血胆红素值低,有统计学意义。结论:治疗ABO HDN应用大剂量IVIG[1 g/(kg·d),连用2天]取得较好的疗效。

Objective：To observe the therapeutic effects of two doses of gammaglobulin （IVIG） for ABO hemolytic disease of newborn （ABO HDN）. Methods：The Children with ABO HDN were randomly divided into two groups, control group was given IVIG 0.5g / （kg . d）, once every three days, the treatment group were given IVIG 1g / （kg . d）, once every two days. Observed regression of jaundice, monitoring of serum bilirubin. Results： Compared with two groups, the treatment group was short time jaundice , 24 hours, 72 hours after treatment , that was low serum bilirubin, it was statistically significant. Conclusions ： Treatment of high dose IVIG [ 1g / （kg . d）, once every 2 days] for ABO HDN achieved better results.