L-荷包牡丹碱对大鼠胃底肌条收缩效应的影响

Effect of L-Dicentrine on Contraction of Rat Stomach Muscle Strips

目的 :研究L 荷包牡丹碱 (L D)对 5 HT ,Histamine,K+ ,Ca2 + 引起的大鼠胃底肌条收缩效应的影响。方法 :采用大鼠胃底肌条的离体实验法 ,观察L D对其收缩效应的影响。结果 :L D及罂粟碱 (pap)对 5 HT ,His tamine ,K+ 及Ca2 + 诱发的大鼠胃底肌条的收缩均有显著的对抗作用。呈现非竞争性拮抗。在无Ca2 + 液中两药均能抑制 5 HT诱发的收缩 ,提示两药对胃底肌条依赖细胞内Ca2 + 所致收缩均有显著的抑制 ,当恢复细胞外Ca2 + 浓度后 ,L D对胃底肌条依赖细胞外Ca2 + 的收缩有抑制作用 ,而 pap无影响。 结论 :L D具有松弛胃底肌条的作用。

Objective:To study the effect of L dicentrine on the contraction of rat stomach muscle strips induced by 5 HT, histamine K + and Ca 2+ .Method:In vitro experimenting on rat stomach muscle strips.Results:The contraction of the strips induced by 5 HT histamine K + and Ca 2+ after high K + depolarization was markedly inhibited by L dicentrine or papaverine,showing a non competitive antagonism.The contraction induced by 5 HT was inhibited by L dicentrine in Ca 2+ free solution.L Dicentrine inhibited the contraction induced by 5 HT,depending on Ca 2+ released from the intracellular store.When the Ca 2+ concentration in both solutions was restored,L dicentrine did not influence the contraction significantly.Conclusion:L-Dicentrine could relax the rat stomach smooth muscle.In rat stomach smooth muscles there exist 5 HT receptors. [