成年女性阴道炎患者支原体感染趋势及耐药性分析

Trends and drug resistance of mycoplasma infection in adult female patients

目的分析2010～2011年门诊妇科女性患者阴道分泌物解脲支原体(Uu)和人型支原体(Mh)的分布情况及其对临床常用的9种抗菌药物的敏感性。方法采用液体培养方法半定量鉴定Uu和Mh,同时进行9种抗菌药物敏感性试验。结果 2010～2011年共检测门诊妇科602例患者阴道分泌物标本,送检标本患者年龄小于20岁6例,占1.0%,20～40岁有514例,占85.4%,大于40岁82例,占13.6%。检出阳性样本359例(59.6%),其中单纯Uu阳性255例(42.4%),单纯Mh阳性15例(2.5%),Uu合并Mh阳性89例(14.8%);Uu药物敏感性试验结果显示抗菌药物敏感性前3位分别为美满霉素、强力霉素、交沙霉素;Mh药物敏感结果显示抗菌药物敏感试验结果显示前3位分别为美满霉素、强力霉素、克拉霉素;Uu合并Mh药物敏感性前3位分别为美满霉素、强力霉素、交沙霉素,其耐药性明显增强。结论单纯Uu感染率较高,Mh合并Uu感染的耐药性明显增强,应结合药敏试验合理选择抗菌药物。

Objective To analyze the the distributions of ureaplasma urealyticum （Uu） and mycoplasma homi nis （Mh） from gynecological vaginal secretions of female outpatients from 2010 to 2011, also to analyze drug sensitivities of them to 9 common clinical antibiotics. Methods Ureaplasma and mycoplasma hominis were identified by semiquantitative liquid culture method,meanwhile drug susceptibility testing of 9 kinds of antibiotics were analyzed. Results From 2010 to 2011 ,gynecological specimens of vaginal secretions from 602 outpatients were detected,in all the patients,6 cases were younger than 20 years old（ 1.0% ） ,514 cases （85.4%）aged from 20 to 40,82 cases （13.6%） were older than 40 years old. 359 cases （59.6%） were positive,in which,255 cases （42.4%）were positive for ureaplasma urealyticum （Uu）, 15 cases （2.5 % ） were positive for mycoplasma hominis （ Mh）, of 89 cases（ 14.8% ） were positive for both ureaplasma urealyticum and myeoplasma hominis. Ureaplasma urealyticum antimicrobial susceptibility results showed that sensitive rates ranked first to third were minocyeline,doxycyeline and josamycin. Mcoplasma hominis susceptibility results showed sensitive rates ranked first to third were minocycline,doxycyclin and clamycin. Uu and Mh susceptibility results showed sensitive rates ranked first to third were doxycyeline,minocycline and josamycin. Conclusion Uu infection rate is higher, the infection of Mh and Uu has high drug sensitive rate. It chould choose reasonable antibiotics according to drug suscemibilitv test.