反复呼吸道感染患儿微量元素和免疫功能水平的测定与分析

Determination and analysis of serum trace elements and immune indexes of children with recurrent respiratory infection

目的探讨全血微量元素Cu、Fe、Zn、Ca、Mg与反复呼吸道感染患儿免疫指标的关系。方法用原子吸收光谱法和免疫散射比浊方法测定56例反复呼吸道感染患儿(RRI组)全血中微量元素和血清免疫球蛋白的含量,并与55例健康儿童(对照组)全血中微量元素和血清免疫球蛋白的含量进行比较。结果 RRI组全血中Zn、Fe、Ca含量明显低于对照组(P<0.01),同时血清IgA、IgG含量明显低于对照组(P<0.01)。结论反复呼吸道感染患儿存在Zn、Fe、Ca含量的缺乏,同时低锌也是造成免疫功能低下的原因之一,需临床医师特别注意,对反复呼吸道感染患者需常规检测微量元素,尤其Zn,并及时补充。

Objective To investigate the relationship between whole blood trace elements of Cu,Fe, Zn,Ca, Mg and serum immune indices of children with recurrent respiratory infection （RRI）. Methods The levels of the whole blood trace elements of Cu, Fe, Zn, Ca and Mg in 56 children with RRI were measured by atomic absorption spectrometric method and serum immunoglobulin were measured by immune nephelometry method, meanwhile, the relationship between deficiency of whole blood trace elements of Cu, Fe, Zn, Ca, Mg and serum immune indices of children with RRI were analyzed, and also compared with 55 healthy children. Results The levels of whole blood trace elements of Zn,Cu and Ca in children with RRI was significantly lower than those in normal control group （P〈 0.01）. Meanwhile serum IgA,IgG contents were obviously lower than these in control group （P〈0.01）. Conclusion Children with repeated respiratory tract infection lack of Zn, Fe, Ca, meantime lacking of Zn could cause low im mune function. The trace elements should be measured routinely in children with RRI,the appropriate content needs to be supplemented if the levels trace elements are low.