血清间皮素、CA199及CA125在卵巢癌中的变化及其临床意义

Expression and Clinical Significance of Serum Mesothelin, CA199 and CA125 Levels in the Diagnosis of Ovarian Cancer

目的探讨卵巢癌患者血清间皮素、CA199及CA125水平的变化及其临床诊断价值。方法本次研究共分为3组:卵巢癌患者组(n=115)、卵巢良性疾病患者组(n=115)和健康对照者(n=115),采用化学发光方法检测各组血清中间皮素、CA199及CA125的水平。结果卵巢癌患者血清间皮素、CA199及CA125的水平均明显高于卵巢良性疾病组和健康对照组,差异均具有统计学意义(P<0.05);而卵巢良性疾病患者组和对照组之间血清间皮素、CA199及CA125的水平差异无统计学意义(P>0.05)。联合应用间皮素、CA199及CA125诊断卵巢癌的特异度和灵敏度均明显高于三者单独及两两联合检测,差异具有统计学意义(P<0.05),而间皮素、CA199及CA125单独检测与两两联合检测相比,其灵敏度和特异度均无统计学差异。结论间皮素、CA199及CA125对于卵巢癌患者的诊断具有重要的临床意义,联合应用间皮素、CA199及CA125能够提高诊断的特异性和灵敏度,具有很好的临床应用价值。

Objective To investigate the application value of detection of Mesothelin, CA199 and CA125 levels in the diagnosis of ovarian cancer. Methods In this study included were 115 cases of ovarian cancer, 115 patients with ovarian benign disease, and 115 healthy people （control group）. Enzyme linked immunosorbent assay （ELISA） was used to detect their serum levels of Mesothelin, CA199 and CA125. Results The serum Mesothelin, CA125 and CA199 levels in ovarian cancer were significantly higher than those of patients with ovarian benign disease and control group （P〈0.05）. There was no significant difference in serum Mesothelin, CA125 and CA199 levels between patients with ovarian benign disease and control group （P〉 0.05）. The sensitivity and specificity of combined detection of serum Mesothelin, CA199 and CA125 were significandy higher than detection of any one or any two of them （P〈 0.05）, but no significant difference of sensitivity and specificity was found between detection ofserurn Mesothelin, CA199 and CA125 alone and detection of any two. Conclusion Combination detection of serum Mesothelin, CA199 and CA125 can promote the diagnosis of ovarian cancer, elevate the accuracy, and has good clinical effects.