裴瑞霞加味二冬汤联合西药治疗肺肾气阴亏虚型2型糖尿病随机平行对照研究

Pei Ruixia's Modified Er Dong Tang Combined with Western Medicine Therapy Type 2 Diabetes of Lung and Kidney Qi Yin Deficiency Randomized and Controlled Study

[目的]观察裴瑞霞加味二冬汤联合西药治疗肺肾气阴亏虚型2型糖尿病疗效。[方法]使用随机平行对照方法,将80例住院患者按随机数字表法随机分为两组,均保持糖尿病饮食、运动、生活规律,降压、降糖、扩冠等常规治疗,停用治疗本病的其他中药及一般预防性用药,两组间用药基本保持平衡。对照组40例吡格列酮胶囊、二甲双胍肠溶片常规西药降糖。治疗组40例在对照组基础上给予加味二冬汤(天冬、麦冬、天花粉各15g,黄芩6g,知母12g,甘草10g,北沙参15g,荷叶10g)1剂/d,水煎服,早晚分服。观测空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbAlc)。均连续治疗3个月为1疗程。连续治疗1疗程,判定疗效。[结果]治疗组临床控制0例,显效27例,有效9例,无效4例,总有效率90.00%。对照组临床控制0例,显效12例,有效13例,无效15例,总有效率62.50%。治疗组疗效优于对照组(P<0.01)。两组FBG,2hPG,HbAlc均明显降低(P<0.01),组间无明显差异(P>0.05)。[结论]加味二冬汤对治疗肺肾气阴亏虚型2型糖尿病疗效满意。

[ Objective ] Observe the efficacy of Pei Ruixia~ Modified Er Dong Tang combined with Western medicine therapy lung and kidney Qi Yin deficiency type 2 diabetes. [ Methods ] The method of randomized parallel controlled is used, 80 cases of hospitalized patients were randomly divided into two groups by random number table, to keep diabetic diet, exercise, patterns of life, blood pressure, blood glucose, expansion of the crown and other conventional therapy, the Chinese medicine and general preventive medication belong the therapy of the disease were stopped, the medication between the two groups remained balanced. Control group, 40 cases of pioglitazone capsule, metformin enteric - coated tablets of conventional Western medicine hypoglycemic. 40 cases in the control group on the basis of the treatment group to give Modified Er Dong Tang. （ Aspartame, Radix, Trichosanthes the 15g, Skullcap 6g, Anemarrhena 12g, Licorice 10g, North Ade- nophora 15g, Lotus Leaf 10g） 1 dose of/ d, water simmer in water, morning and evening hours service. Observe the fasting plasma glucose （FPG） , 2 -hour postprandial blood glucose （2hPG） , glycosylated hemoglo- bin （HbAlc）. Are continuous treatment for 3 months course of treatment. Continuous therapy a course of treatment, to determine the efficacy. [ Results] Treatment group Control 0 cases, cured 27 cases, effective 9 cases, no effective 4 cases, the total efficiency of 90.00%. Control group, the clinical control of 0 cases, 12 cases markedly effective in 13 cases, no effective 15 cases, the total efficiency of 62.50%. Treatment group is more effective than the control group （P 〈 0.01 ）. Two sets of FBG, 2hPG, HbAlc were significantly lower （ P 〈 0.01 ） , no significant differences between the groups （ P 〉 0.05 ）. [ Conclusion ] Modified Er Dong Tang for the therapy of lung and kidney Qi Yin - deficiency type 2 diabetes with a satisfactory outcome.