雾化吸入布地奈德对咳嗽变异性哮喘的疗效及其对患者血清细胞因子水平的影响

The effect of inhalation budesonide in the treatment of cough variant asthma and its influence on serum cytoklne

目的观察雾化吸入布地奈德（普米克）治疗咳嗽变异性哮喘（CVA）的效果及其对患者血清细胞因子水平的影响。方法将112例CVA患儿随机分为雾化组和对照组各56例。雾化组采用普米克雾化吸入治疗，对照组采用口服长效B：受体激动剂治疗。治疗3个月后，比较两组疗效及血清细胞因子水平变化。结果治疗3个月后，雾化组有效率为91．07％，显著高于对照组的75．00％（x2=5．13，P〈0．05）；雾化组血清白细胞介素4、γ干扰素、IgE、嗜酸粒细胞计数均显著低于对照组（t=2．10、2．34、27．63、3．13，均P〈0．05）。结论雾化吸入普米克治疗CVA效果较好，且安全性好。

Objective To observe the effect of inhalation budesonide （pulmicort） in the treatment of cough variant asthma and （CVA） its influence on serum cytokine. Methods 112 children with CVA were randomly divided into the atomization group and control group, each group 56 cases. The atomization group was given pulmicort inhalation therapy, and the control group was given oral long-acting β2 agonist treatment. After 3 months of treatment, the ef- ficacy and serum cytokine levels were compared between the two groups. Results 3 months after the treatment, the effective rate of the atomization group was 91.07% ,and significantly higher than that of the control group（75.00% ） （ x2 = 5.13, P 〈 0.05 ） ; The serum interleukin-4, γ-interferon, IgE, eosinophil counts of the atomized group were sig- nificantly lower than those of control group （t = 2.10,2.34,27.63,3.13, all P 〈 0.05 ）. Conclusion The effect of inhalation pulmicort in the treatment of cough variant asthma is good, and has good safety.