摘要
目的探讨妊娠期糖尿病(GDM)患者血尿酸水平与胰岛素抵抗的相关性。方法检测80例GDM患者与40例正常妊娠产妇的血尿酸(uA)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(IRI)等,并将GDM患者按血尿酸水平分为A组(高尿酸血症,血尿酸〉360Ixmol/L)31例和B组(血尿酸正常)49例,观察比较各组间观察指标变化。结果GDM组的FPG、UA、FINS、IRl分别为(7.87±0.69)mmol/L、(308.874-79.12)txmol/L、(15.87±5.12)mU/L、(2.27±0.72),与对照组的(4.57±1.12)mmol/L、(284.57±43.12)μmol/L、(12.57±4.12)mU/L、(1.32±0.62)相比较,差异均有统计学意义(t=17.0842、2.1758、3.5410、7.1247,均P〈0.05)。A组FPG、UA、FINS、IRI分别为(8.38±0.46)mmol/L、(373.97±29.12)txmol/L、(17.32±6.12)mU/L、(2.47±0.12),与B组的(7.644-0.46)mmoL/L、(284.57±33.12)ixmol/L、(14.57±3.12)mU/L、(2.04±0.22)相比较,差异均有统计学意义(t=5.7187、12.3116、2.3185、11.2835,均P〈0.05)。GDM患者血尿酸水平与FINS、IRI、TG呈明显的正相关关系(r=0.839、0.720、0.660,均P〈0.05)。结论GDM患者血尿酸水平与胰岛素抵抗具有相关性。
Objective To investigate the relationship between blood uric acid and insulin resistance in the patients with GDM. Methods The various biochemical parameters such as uric acid ( UA), fasting plasma glucose (FPG) ,fasting insulin(FINS) and insulin resistance index(IRI) were detected in 80 patients with GDM and 40 nor- mal pregnant women. 80 patients with GDM were divided into A group ( hyperuricemia, UA 〉 360μmol/L, 31 cases ) and B group (normouricemia, 49 cases ) to observe and compare the changes of each biochemical parameter. Results Compared to the control group, there were significant differences in FPG [ ( 7.87 ± 0.69 ) mmol/L, t = 17. 0842] ,UA [ ( 308. 87 ± 79. 12 ) μmol/L, t = 2. 1758 ], FINS [ ( 15.87 ± 5. 12 ) mU/L, t = 3. 5410 ] and IRI [ (2.27 ±0.72),t =7. 1247] (all P 〈0.05). There were significant differences in FPG(8.38 ±0.46) mmol/L,TG (373.97 ±29.12)μmol/L,FINS( 15.87± 5. 12)mU/L, IRI(2.47 ±0. 12) between group A and group B(t = 5. 7187,12. 3116,2. 3185,11. 2835, all P 〈 0.05 ). The blood uric acid level was positively related to FINS, IRI, TG in the patients with GDM ( r = 0. 839,0. 720,0. 660, all P 〈 0.05 ). Conclusion There was correlation between the blood uric acid level and insulin resistance in the patients with GDM.
出处
《中国基层医药》
CAS
2012年第18期2750-2751,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
糖尿病
妊娠
尿酸
胰岛素抗药性
Diabetes, gestational
Uric acid
Insulin resistance