期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管生成素信号系统及其相关抗肿瘤药物的研发 被引量：1

Recent Progress in Study of Angiopoietin in Tumor Treatment
原文传递
导出
摘要 血管生成素与它的第二种受体(Tie-2)组成的信号系统——ANG-Tie2——控制着血管成熟和休眠,它是一种特异作用于血管的受体酪氨酸激酶系统。ANG-2因为显著上调多数肿瘤中的血管形成而被认为可以在癌症的治疗上发挥重要作用。ANG-2被认为是在肿瘤组织中主要发挥作用的ANG型。研究发现ANG-2抑制剂能发挥一定的抗肿瘤作用,而ANG-2抑制剂与细胞毒药物,VEGF抗体药物或酪氨酸激酶抑制剂的联合应用相比于单一疗法表现出更加显著的抗肿瘤作用。文章就血管生成素信号系统和相关抗肿瘤药物的研发进行了综述。 The angiopoietin/Tie2 system has been identified as the second vascular-specific receptor tyrosine kinase system control- ling maturation, and quiescence. Angiopoietin-2 （ANG-2） is prominently up-regulated in the host-derived vasculature of most tumors,making it an attractive candidate for antiangiogenie intervention. Inhibition of ANG-2 can slow tumor growth, and the combination of ANG-2 inhibition with cytotoxic drugs, anti-VEGF agents or TKIs （ Tyrosine Kinase Inhibition） showed significantly enhanced antitumor effects compared with monotherapy.
作者 马力 刘煜
机构地区 中国药科大学天然药物活性物质与功能国家重点实验室
出处 《药物生物技术》 CAS CSCD 2012年第4期352-356,共5页 Pharmaceutical Biotechnology
关键词 血管生成素 血管生成素-2 血管生成素信号系统 抗肿瘤 药物联用 Angiopoietin, ANG-2, Angiopoietin/Tie2 System, Antitumor effects, Combination
分类号 R979.1 [医药卫生—药品]
  • 相关文献

参考文献30

  • 1Lee H J,Cho C H,Hwang S J,ei al. Biological characterization of angiopoietin-3 and angiopoietin- 4 [ J ]. The FASEB Journal, 2004,18:1200.
  • 2Saharinen P, Kerkela K, Ekman N, et al. Multiple angiopoietinrecombinant proteins activate the Tiel receptor tyrosine kinaseand promote its interaction with Tie2[ J]. J Cell Biol,2005,169: 239.
  • 3Saharinen P, Eklund L, Miettinen,ei al, Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts [ J ] . Nat Cell Biol, 2008 ,10 : 527.
  • 4Makinde T,Agrawal D K,ei al. Intra and extravascular transmembrane signalling of angiopoietin-1 -Tie2 receptor in health and disease [J]. 7 Cell Mol Merf,2008 ,12:810.
  • 5Eklund L, Olsen B, et al. Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling [J].Exp Cell Res,2006,312:630.
  • 6Zhang J, Fukuhara S, Sako K, et al. Angiopoietin-1 /Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of j beta} -catenin[ J]. J Biol Chem,2011 ,11:345.
  • 7Fiedler U, Reiss Y, Scharpfenecker Mfet al. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation [ J ] . Nat Med, 2006,12 : 235.
  • 8Winderlich M, Keller L, Cagna G,et al. VE-PTP controls blood vessel development by balancing Tie-2 activity [ J]. J Cell Biol, 2009,18S:657.
  • 9Li Z, Huang H, Boland P ,et al. Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis [ J ]. PNAS, 2009,106:22399.
  • 10Nasarre P, Thomas M, Kruse K,et al. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth [ J ]. Cancer fe,2009,69:1324.

同被引文献4

引证文献1

二级引证文献2

药物生物技术
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部