期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

铃蟾肽复合物在肿瘤诊断和治疗中的研究进展

Advances in Research of Bombesin-Targeted Complexes in Tumor Treatment and Diagnosis
原文传递
导出
摘要 铃蟾肽(bombesin,BN)是一种14个氨基酸的多肽,其受体在多种肿瘤系胞中过度表达。铃蟾肽作为一个靶点,在肿瘤治疗和诊断中起重要作用。文章介绍了铃蟾肽的特性及在肿瘤诊断和治疗中的作用,并对其研究进展进行了总结。 Bombesin is a 14 amino acid peptide and the receptors are overexpressed on many kinds of tumor cells, but rarely even hardly expressed in normal tissues. As a target point, bombesin plays an important rule in tumor treatment and diagnosis. In this review, the characteristics of bombesin and role in tumor diagnosis and treatment was described and also the summary of research progress was discussed.
作者 万姝南 顾月清
机构地区 中国药科大学生命科学与技术学院
出处 《药物生物技术》 CAS CSCD 2012年第4期369-372,共4页 Pharmaceutical Biotechnology
关键词 铃蟾肽 肿瘤诊断 治疗 Bombesin, Tumor diagnosis, Treatment
分类号 Q516 [生物学—生物化学] R73 [医药卫生—肿瘤]
  • 相关文献

参考文献32

  • 1Hirotsugu U,Nieves G, Veronica S,et al. Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs [ J ].2011,32(8) :1685.
  • 2Sancho V,Diflorio A,Moody TW,ei al. Bombesin receptor-mediated imaging and cytotoxicity : review and current status [ J ]. Curr Drug Deliv,2011,5(1) :19.
  • 3Rice SL, Roney CA, Daumar P,et al. The next generation of positron emission tomography radiopharmaceuticals in oncology [ J ]. Semin Nucl Med,2011,41(4) :265.
  • 4Hohla F, Schally AV. Targeting gastrin releasing peptide receptors :New options for the therapy and diagnosis of cancer [ J ]. Cell Cycle,2010,9(9) :1738.
  • 5Terry WM, Veronica S, Alessia F,et al. Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation [ J ]. Peptides, 2011,32(8) :1677.
  • 6Okarvi SM,Jammaz IA. Preparation and evaluation of bombesin peptide derivatives as potential tumor imaging agents : effects of structure and composition of amino acid sequence on in vitro and in vivo characteristics [ J ]. Nucl Med Biol,2012,[ Epub ahead of print].
  • 7Faintuch BL, Oliveira EA, Nunez EG, et al. Comparison of two peptide radiotracers for prostate carcinoma targeting [ J]. Clinics (Sao Paulo) ,2012,67(2) :163.
  • 8Graham MM,Menda Y. Radiopeptide imaging and therapy in the United States[ J]. J Nucl Med,,52(2) :56.
  • 9Mendoza-S6nchez AN,Ferro-Flores G, Ocampo-Garcla BE,ef al. Lys3-bombesin conjugated to 99mTc-labelled gold nanoparticles for in vivo gastrin releasing peptide-receptor imaging [ J ]. / Biomed Nanotechnol,2010,6(4) :375.
  • 10Bodei L,Ferone D,Grana CMal. Peptide receptor therapies in neuroendocrine tumors [ J ]. J Endocrinol Invest,2009,32(4):360.

二级参考文献17

  • 1张东明,付敏,马万云,陈瓞延.用激光诱导荧光结合毛细管电泳测定单胺类神经递质[J].仪器仪表学报,2001,22(z2):346-347. 被引量：4
  • 2El-Sayed I, Huang X, El-Sayed, et al. Surface Plasmon Resonance Scattering and Absorption of anti - EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer[J]. NanoLetters. 2005, 5, 829.
  • 3Parak W J, Boudreau R, Gros M L,etal. Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks[J]. Advanced. Materials. 2002, 14 : 882.
  • 4Chan W, Nie S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection[J]. Science 1998, 281:2016.
  • 5Karhanek M, Kemp J, Pourmand N. Single DNA molecule detection using nanopipettes and nanoparticles[J]. Nano Letters. 2005, 5: 403.
  • 6Taton T, Lu G, Mirkin C. Two--color labeling of oligonucleotide arrays via sizeselective scattering of nanoparticle probes [J]. Journal of America Chemical Society, 2001, 123:5164.
  • 7Medintz I, Clapp A, Melinger J. A reagentless biosensing assembly based on quantum dot - Donor F? rster Resonance Energy Transfer[J]. Advanced Materials , 2005, 17: 2450.
  • 8Panyam J, Labbasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue[J]. Advanced drug deliver, 2003, 5: 329.
  • 9Yang P, Sun X, Chiu J, et al. Transferrin--mediated gold nanopartiele cellular uptake[J]. Bioconjugate Chem, 2005, 16: 494.
  • 10Chenevier P, Veyret B, Roux D. Interaction of cationic colloids at the surface of J774 cells: a kinetic analysis[J]. Biophys J, 2000, 79: 1298.

共引文献14

药物生物技术
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部