脑肿瘤与手机使用病例对照研究的Meta分析

Brain tumor and mobile phone use: meta-analysis of case-control studies

目的评价手机使用与脑肿瘤危险性的联系。方法采用Meta分析方法对2000年至2011年发表的关于脑肿瘤与手机使用相关的病例对照研究文献进行定量分析。结果 13篇病例对照研究文献纳入,规律使用手机者未见脑瘤危险性增高;而长期使用手机10年以上者与脑肿瘤发生存在关联(OR=1.11,95%CI:1.01～1.22),长期同侧使用手机发生脑肿瘤危险性增加32%(OR=1.32,95%CI:1.14～1.54)。结论规律使用手机并不增高脑肿瘤发生的风险,长期使用手机可能增加脑肿瘤发生的风险,但分析中的偏倚与混杂因子可能影响因果关系的解释。

Objective To evaluate the association between mobile phone use and brain tumor risk. Methods Metaanalysis method was used to analyze the case-control studies on association between brain tumor and mobile phone use, the data were searched from 2000 to 2011. Results A total of 13 case-control studies were included. Analysis findings showed no increase in risk for regular mobile phone user was seen. A somewhat increased risk was found for long-term mobile phone （OR=1.11; 95% CI： 1.01-1.22）. There were suggestions of an increased risk of brain tumor for ipsilateral exposures in 10 years or more （OR=1.32; 95% CI： 1.14-1.54）. Conclusion Overall, no increase in risk of brain tumor was observed among uses regular using mobile phone. There were suggestions of an increased risk of brain tumor with long-term heavy use of mobile phone, but biases and confounding factors may prevent a causal interpretation.