CYP2E1基因1019位点多态性与肺癌易感性的Meta分析

CYP2E1 gene 1019 polymorphism and the risk on human lung cancer:a Meta-analysis

目的:研究CYP2E1基因1019位点多态性与肺癌易感性的关系。方法:检索数据库,按纳入标准进行筛选,对纳入文献用Review Manager 4.2软件进行Meta分析,得到合并OR值(95%CI),并进行一致性检验及发表偏倚检验。结果:共纳入文献11篇,累积病例1 278例,对照1 568例,与野生纯合基因型c1c1相比较,突变杂合基因型c1c2、突变纯合基因型c2c2和(c1c2+c2c2)合并的OR值分别为0.74(0.63,0.87)、0.90(0.63,1.28)和0.73(0.63,0.86)。结论:CYP2E1基因1019位点c2突变子是肺癌的保护因素。

Objeetive To explore the association between CYP2E1 codon 1019 polymorphism and the risk on human lung cancer. MethodsData bases were searched to select the references consistent with the criteria. Meta-analysis was performed by review manager 4.2 for pool OR value （with 95 %CI）,the heterogeneity was examined,a funnel plot and Egger＇s linear regression method was constructed to check for publication bias,cumulative meta-analysis was also performed. Results A total of 11 case-control studies were collected including 1278 cases and 1568 controls. Compared with the wide-type homozygote cl/cl, the pooled OR value （with 95 %CI） of clc2.c2c2 and （clc2q-c2c2） were 0.74 （0.63,0.87） ,0.90（0.63,1.28） and 0. 73（0. 63,0. 86）. Conclusion The c2 mutation on the codon 1019 of CYP2E1 gene was a protective factor.