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1-磷酸鞘氨醇受体 被引量：3

Sphingosine-1-phosphate receptors
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摘要 1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)对动脉粥样硬化等心血管疾病的发生发展具有重要作用。最近研究发现S1P在不同细胞发挥的生物学效应由其受体(sphingosine-1-phosphate receptor,S1PR)介导,以S1PR及其信号机制为基础的研究及治疗策略成为新的研究热点。本文主要综述S1PR的功能、信号通路及对心血管疾病的影响,为心血管疾病的预防和诊疗提供新的靶点。 Sphingosine-l-phosphate （S1P） plays an important role in the development ofatherosclerosis-related cardiovascular diseases. Recent findings have shown that S1P plays biological effects in different cells mainly through G protein-coupled receptors sphingosine-1- phosphate receptors （S 1PRs）. Therefore, the S 1PRs as well as the signaling mechanism has become the research hot spot. In this review, we summariz recent advance in study of the function, signal pathway and effects of S1PRs in the cardiovascular system diseases, which may provide a new strategy and targets for cardiovascular disease prevention.
作者 张智超 莫中成 刘行 张大棣 易光辉
机构地区 南华大学心血管病研究所动脉硬化湖南省重点实验室
出处 《生命的化学》 CAS CSCD 2012年第4期367-371,共5页 Chemistry of Life
基金 湖南省高等学校科学研究项目(09A078) 留学归国科研启动基金项目(2010XQD46) 国家自然科学基金项目(81100211)资助
关键词 1-磷酸鞘氨醇 G蛋白偶联受体 动脉粥样硬化 心血管系统 Sphingosine-l-phosphate G protein-coupled receptor atherosclerosis cardiovascular system
分类号 R363 [医药卫生—病理学]
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参考文献24

  • 1Wang F et al. Sphingosine-l-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. J Clin Invest, 2010, 120: 3979-3995.
  • 2Kono Met al. Deafness and stria vascularis defects in S1P2 receptor-null mice. JBiol Chem, 2007, 282:10690-10696.
  • 3Ishii Iet al. Selective loss of sphingosine l-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem, 2001, 276:33697-33704.
  • 4Kono Met al. The sphingosine- l-phosphate receptors S 1P 1, S 1P2, and S 1 P3 function coordinately during embryonic angiogenesis. J Biol Chem, 2004, 279:29367-29373.
  • 5Means CK et al. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol, 2007, 292:H2944-H2951.
  • 6Meng H et al. Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system. Dev Dyn, 2009, 238:487-500.
  • 7Wang W et al. Type 4 sphingosine 1 -phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration. FASEB J, 2005, 19:1731-1733.
  • 8Takabe K et al. "Inside-out" signaling of sphingosine-1- phosphate: therapeutic targets. Pharmacol Rev, 2008, 60:181-195.
  • 9Jaillard C et al. Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci, 2005, 25:1459-1469.
  • 10Meyer ZHD et al. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim Biophys Acta, 2007, 1768:923-940.

同被引文献101

  • 1李庆芳,王立生.鞘氨醇激酶调节细胞凋亡的研究进展[J].军事医学科学院院刊,2005,29(1):84-86. 被引量：9
  • 2Meng H, Lee VM. Differential expression of sphingosine-1- plosphate receptors 1-5 in the developing nervous system [J]. Dev Dyn, 2009, 238(2) : 487-500.
  • 3Michel MC, Mulders AC, Jongsma M, et al. Vascular effects of sphingolipids [ J ]. Acta Paediatr Suppl, 2007, 96(455) : 44-48.
  • 4Shoham AB, Malkinson G, Krief S, et al. S1P1 inhibits sprouting angiogenesis during vascular development [ J ]. Development, 2012, 139(20) : 3 859-869.
  • 5Jung B, Obinata H, Galvani S, et al. Flow-regulated endo- thelial SIP receptor-1 signaling sustains vascular develop- ment [J]. Dev Cell, 2012, 23(3) : 600-610.
  • 6Gon Y, Wood MR, Kiosses WB, et al. S1 P3 receptor-in- duced reorganization of epithelial tight junctions compromi- ses lung barrier integrity and is potentiated by TNF [ J ]. Proc Natl Acad Sci USA, 2005, 102(26) : 9 270-275.
  • 7Nofer JR, van der Giet M, Tolle M, et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid re- ceptor S1P3 [J]. J Clin Invest, 2004, 113(4) : 569-581.
  • 8Lu H, Yuan H, Chen S, et al. Senescent endothelial dys- function is attributed to the up-regulation of sphingosine-1- phosphate receptor-2 in aged rats [ J ]. Mol Cell Bio- chem, 2012, 363(1-2): 217-224.
  • 9Lorenz JN, Arend LJ, Robitz R, et al. Vascular dysfunc-tion in S1P2 sphingosine 1-phosphate receptor knockout mice [ J ]. Am J Physiol Regul Integr Comp Physiol, 2007, 292( 1 ) : R440-446.
  • 10Salomone S, Potts EM, Tyndall S, et al. Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools [ J ]. Br J Pharmacol, 2008, 153 ( 1 ) : 140-147.

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生命的化学
2012年 第4期

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