盐酸帕洛诺司琼用于麻醉术后止吐的效果观察

Therapeutic Observation of Palonosetron Hydrochloride for Vomiting after Anesthesia Surgery

目的:观察盐酸帕洛诺司琼用于麻醉术后出现的急性及迟发性呕吐的疗效和不良反应。方法:选择腹腔镜胆囊切除手术的60例患者,随机分为试验组与对照组,每组30例,在麻醉诱导前,试验组给予盐酸帕洛诺司琼0.25mg,对照组给予盐酸托烷司琼5mg,分别记录2组麻醉术后72h内止吐效果和不良反应。结果:试验组与对照组对麻醉术后出现急性呕吐的完全控制率分别为80.0%、70.0%(P>0.05),急性呕吐发生率均为13.3%,但迟发性呕吐发生率分别为6.7%、16.7%(P<0.05);2组主要不良反应为腹胀、头痛及便秘,试验组与对照组的总不良反应发生率分别为23.3%、20.0%(P>0.05)。结论:2种5-羟色胺3(5-HT3)受体拮抗药均有较好的止吐作用,而盐酸帕洛诺司琼对于迟发性呕吐效果更好。

OBJECTIVE： To observe therapeutic efficacy and adverse drug reaction of palonosetron hydrochloride for acute and delayed vomiting after anesthesia surgery. METHODS： 60 patients with laparoscopic cholecystectomy were randomly divided into test group and control group with 30 patients in each group. Before induction of anesthesia, test group was given palonosetron hy- drochloride 0.25 mg and control group was given tropisetron hydrochloride 5 mg. Antiemetic effects and adverse drug reactions of 2 groups were recorded within 72 h after surgery. RESULTS： The complete control rates of acute vomiting in test group and control group after anesthesia surgery were 80.0% and 70.0% respectively （P〉0.05）, the incidence of acute vomiting was 13.3% and that of delayed vomiting were 6.7% and 16.7% respectively （P〈Z0.05） ; main adverse drug reactions were bloating, headache and con- stipation in 2 groups and the incidences of adverse drug reaction were 23.3% and 20.0% （P〉0.05）. CONCLUSION： These two 5-HT3 receptor antagonists both have good antiemetic effect, but palonosetron hydrochloride is better in the treatment of delayed vomiting.