杂多酸环戊二烯钒衍生物的合成、谱学性质及抗肿瘤活性

Synthesis,Spectroscopic Characterization and Antitumoral Activities of Cyclopentadienylvanadium Derivatives of Polyoxotungstates

合成了杂多酸环戊二烯钒衍生物[Bu4N]4[(CpV)PW11O39](1),[Bu4N]4H[(CpV)SiW11O39](2)和[Bu4N]4[A-β-(η5-CpV)SiW9V3O40](3),并通过元素分析、IR、51 V和183 W NMR谱进行了结构表征。结果表明配合物(1)和(2)为结合型有机金属配合物,(3)为支撑型杂多酸有机金属配合物。体外抗肿瘤活性研究表明化合物(1)对HL-60和B16均具有一定的抑制作用。

Cyclopentadienylvanadium derivatives of polyoxotungstates 4[（CpV）PW11O39]（1）,4H[（CpV）SiW11O39]（2） and 4[A-β-（η5-CpV）SiW9V3O40]（3） were synthesized,and characterized by elemental analysis,IR,51V and 183W NMR spectroscopy.Experiment results indicate that（1） and（2） are polyoxometalate-incorporated organometallic complexes,and（3） is a polyoxometalate supported organometallic complex.Antitumoral activities were examined by MTT method.Experiment results indicate that the title complexes did exhibit to a certainty antitumor activity for HL-60 and B16.