手术治疗甲状腺微小乳头状癌预后及其影响因素分析

Analysis of the prognosis and impact factors of papillary thyroid microcaricinoma treated by surgeryZ

目的分析手术治疗甲状腺微小乳头状癌(PTMC)预后及其影响因素。方法回顾性分析本院手术治疗的128例PTMC患者的临床和随访资料,总结分析患者术后预后情况;根据随访生存情况,将患者分为死亡组和非死亡组,比较两组患者相关参数的差异。结果 16例患者术后出现并发症,其中,声带麻痹7例,甲状旁腺功能减退9例;18例患者术后肿瘤复发,其中,局部区域复发15例,肺转移患者3例;术后5年生存率为93.75%(120/128)。死亡组患者年龄、有淋巴结转移比例和远处转移比例显著高于非死亡组(P<0.05);两组患者在性别、病程、肿瘤大小、手术方式、肿瘤复发方面差异无统计学意义(P>0.05)。结论手术治疗是PTMC患者较理想的选择,年龄、淋巴结转移和远处转移可能是影响其预后的因素。

Objective To analyze the prognosis and impact factors of papillary thyroid microcaricinoma treated by surgery. Methods The clinical and following-up data of 128 patients with papillary thyroid microearicinoma treated by surgery were analyzed retrospectively. According to survival, all patients were divided into death group and non-death group. The pa- rameters were compared between two groups. Results Among the 16 patients with postoperative complications, 7 patients were found with vocal cord paralysis, 9 patients were found with hypoparathyroidism. Among the 18 patients with tumor recurrence, 15 patients were found with locoregional recurrence, 3 patients were found with lung metastases. The 5-year sur- vival rate of 128 patients was 93.75% （120/128）. Compared with non-death group, the age, lymph node metastasis and distant metastasis of death group had significant differences （P 〈 0.05）. There were not significant differences between two groups in sex, tumor size, surgical approach and tumor recurrence （P 〉 0.05）. Conclusion Surgical treatment is suggested to be a good treatment for those patients. The factors of age, lymph node metastasis and distant metastasis may impact the prognosis.