血浆同型半胱氨酸检测在短暂性脑缺血发作临床转归中的研究

The relevance between plasma homocysteine levels and transient ischemic attack

目的探讨短暂性脑缺血发作(transient ischemic attack,TIA)与血浆同型半胱氨酸(homocysteine,Hcy)的关系。方法选取2011年2月～2012年2月在本科住院的短暂性脑缺血发作患者50例为观察组,选取同期健康体检对象45名为对照组,进行血浆同型半胱氨酸检测并比较。结果观察组血浆同型半胱氨酸为(18.59±2.09)μmol/L,对照组为(10.32±2.21)μmol/L,差异有统计学意义(P<0.05);TIA不同临床转归患者的Hcy水平差异有统计学意义(P<0.05)。结论 TIA进展为脑梗死与血清同型半胱氨酸的水平有关系,血清同型半胱氨酸可作为预测及评价TIA的重要指标之一。

Objective To observe the relevance of transient ischemic attack （TIA） and plasma homocystein （Hcy） level. Methods Fifty patients with transient ischemic attack who were treated in our hospital from February 20ll to February 2012 were selected as the observation group, forty five cases of normal physical examination were selected as the control group. P^asma homocysteine levels were detected and compared between the two groups. Results The patients＂ plasma concentration of homocysteine was （18.59±2.09） μmol/L in observation group,while it was （10.32±2.21） μmol/L in control group. There was statistically significant difference between the two groups （P 〈 0.05）; there were statistically significant differences on Hey between patients of different clinical outcome （P 〈 0.05）. Conclusion The occurrence of ischemic stroke is related to the level of serum Hcy, which probably is regarded as a good index to predict and evaluate the progressing of TIA.