Ⅲ型慢性前列腺炎患者前列腺按摩液中IL-8、IL-10的表达及意义

IL-8 and IL-10 in prostatic secretions indications in chronic prostatitis Ⅲ

目的观察IL-8和IL-10在Ⅲ型慢性前列腺炎(CAP)患者的前列腺按摩液(EPS)中的表达及临床分型意义,探讨其可能的发病机制。方法收集2012年2～6月在本院泌尿外科门诊就诊的慢性前列腺炎/慢性盆底疼痛综合征(CAP/CPPS)患者共58例,其中,30例ⅢA型患者纳入A组,28例ⅢB型患者纳入B组,同时选择同期20名本院体检的健康男性纳入对照组,采用双抗体夹心ABC-ELISA测定3组患者EPS中IL-8、IL-10含量并进行比较,同时按国际前列腺炎症状评分标准评定患者病情程度并进行相关性研究。结果 A组与B组患者EPS中IL-8及IL-10含量显著高于对照组,同时A组患者中EPS中IL-8的含量明显高于B组,差异均具有统计学意义(P<0.05),而A组患者EPS中IL-10的含量与B组差异无统计学意义(P>0.05);IL-8含量与CPSI评分呈正相关,IL-10含量则与疼痛不适症状评分呈正相关。结论检测Ⅲ型CAP患者的EPS中IL-8和IL-10水平有助于对其分型进行诊断,并可作为了解其病情程度的有价值的参考指标。

Objective To observe the expression and clinical significance of IL-8 and IL-10 in prostatic （EPS） in patients of type m of chronic prostatitis （CAP）, to explore its possible pathogenesis. Methods A total of 58 cases of urology clinic of chronic prostatitis/ehronic pelvic pain syndrome （CAP/CPPS） patients in our hospital from February 2012 to June 2012 were collected, 30 cases of type ]ILIA patients were collected into group A, 28 cases of type m B patients were collected in- to group B, and 20 cases of medical healthy male subjects at the same time were collected into the control group, the dou- ble antibody sandwich ABC-ELISA determination was used to detect and compare IL-8, IL-10 levels in the EPS in the three groups, at the same time prostatitis symptom score according to the international standard assessment of the severity of patients was assessed, and their correlation were analyzed. Results IL-8 and IL-10 in patients＇ EPS in group A and group B were significantly higher than the control group , and the IL-8 in the patients＇ EPS in group A was significantly higher than that in the group B, the differences was statistically significant （P 〈 0.05）, while difference of IL-10 in the pa- tients＇ EPS in the group A and group B was not significant （P 〉 0.05）; It showed a positive correlation between 1L-8 and CPSI score, IL-10 and the score of pain discomfort symptom was positively correlated. Conclusion The detection of IL-8 and IL-10 levels in EPS of patients of type 111 CAP is contribute to diagnostic typing, and it can serve as the severity of valuable reference.