氟哌噻吨美利曲辛片联合氯硝西泮治疗躯体形式障碍的临床分析

Clinical analysis of flupentixol and melitracen tablets combined with clonazepam in the treatment of somatoform disorders

目的比较氟哌噻吨美利曲辛片联合氯硝西泮与单用氟哌噻吨美利曲辛片治疗躯体形式障碍的临床疗效及安全性。方法将98例躯体形式障碍患者随机分成氟哌噻吨美利曲辛片联合氯硝西泮组(研究组)及氟哌噻吨美利曲辛片组(对照组),各49例。观察两组的治疗效果。治疗疗程为6周,用汉密尔顿抑郁量表(HAMD)评定临床疗效。结果研究组显效率为89.80%,有效率为97.96%;对照组显效率为93.88%,有效率为97.96%。治疗前后HAMD评分比较发现,第2天后两组评分比较差异有统计学意义(P<0.01),两组在治疗第4周后评分比较,差异无统计学意义(P>0.05),两组疗效相当。研究组所见不良反应有困倦、心悸,对照组多为失眠,但都比较轻微。结论氟哌噻吨美利曲辛片联合氯硝西泮治疗躯体形式障碍比单用氟哌噻吨美利曲辛片起效快,疗效肯定,不良反应轻微。

Objective To compare the clinical effect and safety of flupentixol and melitracen tablets combined with clonazepam and single use of flupentixol and melitraeen tablets in the treatment of somatoform disorders. Methods Ninetyeight cases of patients with somatoform disorders were randomly divided into flupentixol and melitracen tablets combined with clonazepam group （study group） and flupentixol and melitracen tablets group （control group）, with 49 cases in each group. The treatment effect was observed. The treatment course was 6 weeks. The Hamilton depression rating scale （HAMD） was used to evaluate the clinical efficacy. Results In the study group, the obvious effective rate was 89.80%, and the effeetive rate was 97.96%. In the control group, the obvious effective rate was 93.88%, and the effective rate was 97.96%. Compared with the HAMD scores before and after treatment, there were significant differences of the scores in the second day between the two groups （P 〈 0.01）. The efficacy of the two groups was similar. The adverse reactions of the study group were tiredness and palpitation, while the control group presented almost insomnia. Both adverse reactions were slight. Conclusion Flupentixol and melitracen tablets combined with clonazepam in the treatment of somatoform disorders has faster effect onset time, definite curative effect and lighter adverse reactions than single use of flupentixol and melitracen tablets.