喉癌间质肥大细胞与其他浸润细胞的关系

Relationship between mast cells and other infiltrated cells in the stroma of laryngeal carcinoma

为了探讨肥大细胞 (MC)在喉癌间质反应中的作用 ,用光镜、电镜技术研究了 45例喉鳞癌组织及癌旁组织中MC形态学特征及其与其他浸润细胞的关系。结果发现癌间质中MC呈活跃的脱颗粒状态 ,并与淋巴细胞、浆细胞、巨噬细胞、嗜酸粒细胞、成纤维细胞关系密切。癌旁组织中淋巴细胞浸润程度高的 ,MC数量多 (P <0 0 1) ;癌组织中有明显胶原纤维包裹的 ,MC数量多 (P <0 0 1)。结果提示 :喉癌间质中的MC与其他浸润细胞有协同作用 。

To explore the effect of tumor-associated mast cells and other infiltrated cells in the stroma of laryngeal carcinoma.Forty-five specimens were divided into two groups:tumor group ( n =35) and peritumor group (n =10).Results:Mast cells in the tumor group exhibited active degranulation,and contacted closely with lymphocytes, plasma cells, macrophages, eosinophils and fibroblasts. The number of mast cells was significantly higher in the peritumor group with lymphocytes infiltration than that with few lymphocyte infiltration. The number of mast cells was significantly higher in the tumor group with more collagenous fiber than that with few collagenous fiber. These suggest that mast cells and other infiltrated cells may together play a critical role in the host antitumor immune reaction.