益气养阴活血方对气阴两虚血瘀型糖尿病患者血浆内皮素与一氧化氮水平的影响

Effect of Yiqi Yangyin Huoxue Recipe on Endothelin and Nitric Oxide of Type 2 Diabetic Patients with Deficiency of Both Qi-Yin and Blood Stasis Syndrome

目的 :探讨益气养阴活血方对气阴两虚血瘀型糖尿病患者血浆内皮素 (ET)、一氧化氮 (NO)水平的影响。方法 :将 80例 2型糖尿病患者随机分为治疗组及对照组 ,观察益气养阴活血方对气阴两虚血瘀型糖尿病患者血糖、临床症状及血浆ET、NO水平的影响 ,并与糖适平对照组进行对比研究。结果 :治疗组治疗后血浆ET水平明显下降 ,有显著性意义 (P <0 0 1) ,NO水平无明显改变 ,益气养阴活血方降低血糖的总有效率为空腹血糖 (FBG) 87 80 % ,餐后 2h血糖 (PBG) 90 2 4 %。结论 :益气养阴活血方可降低患者血浆ET水平 ,有一定保护糖尿病患者内皮细胞功能的作用 ,并可降低血糖、改善临床症状 ,对治疗糖尿病及预防其血管并发症有积极意义。

To study the effect of Yiqi Yangyin Huoxue recipe (YQYYHX) in treating type 2 diabetes mellitus (DM) patients with deficiency of both Qi Yin (DQY) and blood stasis Syndrome. Methods: Forty one type 2 DM patients compared with those in the control group were observed. Results: After treatment, the endothelin (ET) level of the treated group reduced significantly, and the total effective rate of blood sugar lowering were as follows: Fasting blood glucose (FBG) 87.80%, 2 hours postprandial plasma blood glucose (PBG) 90.24%. Conclusion: YQYYHX is effective in improving the patient′s vascular endothelia cell functions by reducing the plasma ET level, clinical symptoms and blood sugar lowering.