摘要
目的 :探讨草果知母汤抗痫作用的分子生物学机制。方法 :选用SD大鼠以戊四唑 (PTZ)诱导产生癫痫动物模型 ,应用分子原位杂交技术观察草果知母汤对PTZ点燃癫痫大鼠脑内c fos、c jun基因表达的影响。结果 :PTZ点燃癫痫大鼠脑内c fos、c jun基因表达明显增强 ,草果知母汤能明显阻断其表达 ,并显示出良好的抗痫作用。结论 :草果知母汤的抗痫作用机制可能与降低脑内c fos、c jun基因表达水平有关。
To investigate the molecular biological mechanism of anti epileptic effect of Tsaoko Anemarrhenae decoction (TAD) on epileptic model rats. Methods: The pentylenetetrazol (PTZ) induced epileptic Sprague Dawley rats were selected as the animal model. The effects of TAD on the c fos, c jun gene expression in the rats' brain were observed by in situ hybridisation. Results: The c fos, c jun gene expression was obviously increased, TAD could effectively block the gene expression of c fos, c jun, showing better antiepileptic effect. Conclusion: The mechanism of TAD anti epileptic effect might be correlated to the decrease of c fos, c jun gene expression.
出处
《中国中西医结合杂志》
CSCD
北大核心
2000年第8期606-608,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局科研基金!资助课题 (No .98Y1 1 1 )
