不稳定心绞痛危险分层与心脑血管病的相关性分析

Correlation analysis of the risk stratification of unstable angina with cardio-cerebrovascular disease

目的探讨心绞痛危险分层与心脑血管病的相关性。方法对2010年1月~2011年5月来我院诊治的180例不同危险分层的心绞痛患者,分别进行QRS波碎裂、缺血修饰蛋白（IMA）、钠尿肽（BNP）、动脉粥样斑块及内膜-中膜厚度（IMT）的检测,利用冠脉造影对冠脉病变支数和冠脉狭窄程度进行检测,以及经颅多普勒（TCD）检查。结果与低危组（21.7%）相比,中危组（43.3%）、高危组（65.0%）出现QRS波碎裂的发生率明显增多（P〈0.05）。与低危组相比,中、高危组IMA水平明显升高（P〈0.05）。与低危组相比,中、高危组钠尿肽BNP明显提高（P〈0.05）。随着危险分层的增高,冠脉动脉病变支数逐渐由单支病变转变为多支病变,冠脉狭窄程度逐渐增加,TCD检查异常率升高。结论心绞痛危险分层越高,发生心脑血管病的几率就越高。

Objective To study the correlation of the risk stratification of unstable angina with cardio-eerebrovascular dis- ease. Methods 180 angina patients with different risk stratification during the period from January 2010 to May 2011 in our hospital were measured respectively QRS complex fragmentation, isehemia-medified protein （IMA）, natriuretie peptide （BNP）, atherosclerotic plaque and intima-media thickness （IMT）. The coronary lesions and coronary stenosis were detected by coronary angiography, TCD measures were assayed by transcranial Doppler examination. Results Compared with the low risk group （21.7%）, the QRS complex fragmentation was significantly increased in middle and high risk groups （43.3% and 65.0%） （P 〈 0.05）. Compared with the low risk group, the IMA levels increased significantly in middle and high risk groups （P 〈 0.05）. Compared with the low risk group , the natriuretic peptide BNP significantly increased in middle and high risk groups （P 〈 0.05）. With the increase of the risk stratification, the coronary arterial lesions gradually shifted from single- vessel disease with muhivessel disease, the abnormal TCD rate increased with the coronary artery stenosis gradually in- creased. Conclusion With the higher the risk stratification of angina, the cardio-cerebrovascular disease is the higher occurrence.