期刊文献+

血清氮端脑钠肽及脑钠肽在新生儿败血症合并心肌损伤时的临床意义 被引量:2

Clinical significance on detection of serum NT-proBNP and BNP in diagnosis of cardiac injury in neonatal sepsis
下载PDF
导出
摘要 目的探讨脑钠肽(BNP)及氮端脑钠肽(NT-proBNP)在新生儿败血症心肌损伤诊断中的价值。方法选择37例新生儿败血症合并心功能异常患儿作为病例组,15例健康新生儿作为对照组参与本研究,采用ROSS新生儿心功能分级将患儿分为心功能Ⅰ、Ⅱ和Ⅲ级;采用心脏超声检测患儿左室射血分数(LVEF);检测患儿血浆BNP及NT-proBNP水平,并在不同心功能分级患儿以及正常新生儿之间进行比较。结果病例组血浆BNP及NT-proBNP水平较对照组显著升高,差异具有统计学意义(P<0.05);随着患儿心功能评级的上升,血浆BNP及NT-proBNP水平水平不断显著升高,LVEF不断显著降低,差异均具有统计学意义(均P<0.05);在心功能Ⅰ级患儿,血浆NT-proBNP的升高率显著高于BNP升高率(P<0.05)。结论血浆BNP及NT-proBNP水平可作为新生儿败血症心肌损伤诊断的良好辅助指标;对于早期心肌损伤的诊断,NT-proBNP优于BNP。 Objective To explore the value of detection of BNP and NT- proBNP in neonatal sepsis. Methods 37 cases of neonatus with neonatal sepsis and abnormal cardiac function were selected as case group and 15 healthy neonates as control group were selected. ROSS classification was applied to put patients into class Ⅰ , Ⅱ, Ⅲ; LVEF was tested by cardiac uhrasound; levels of BNP and NT-proBNP among class Ⅰ , Ⅱ, Ⅲ and control group were detected and compared. Results Increased levels of BNP and NT-proBNP were found significantly in case group than in control group (P 〈 0.05); along with upgrade of cardiac function classification and decrease of LVEF, increased levels of BNP and NT-proBNP were found significantly (P 〈 0.05); in cardiac function class I, increase rate of NT-proBNP was found significantly higher than that of BNP (P 〈 0.05). Conclusion Detection of BNP and NT-pro BNP could be utilized as auxiliary indexes in diagnosis of cardiac injury in neonatal sepsis; detection of NT-proBNP is more valuable than BNP in diagnosis of early stage cardiac injury in neonatal sepsis.
作者 谷成祥
出处 《中国医药导报》 CAS 2012年第23期89-90,92,共3页 China Medical Herald
关键词 新生儿败血症 脑钠肽 氮端脑钠肽 心肌损伤 Neonatal sepsis BNP NT-proBNP Cardiac injury
  • 相关文献

参考文献9

二级参考文献44

共引文献1064

同被引文献20

  • 1史晓敏,徐国宾,夏铁安.N末端B型钠尿肽原对充血性心力衰竭患者预后及危险分层评价的价值[J].中华检验医学杂志,2006,29(1):27-30. 被引量:56
  • 2Kotaska K,Popelova J,Tiserova M,et al.NT-pro BNP and BNP values in cardiac patients with different degree of left ventricular systolic dysfunction.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2006,150:125-130.
  • 3Barbosa MM,Nunes Mdo C,Ribeiro AL,et al.N-terminal pro BNP levels in patients with Chagas disease:a marker of systolic and diastolic dysfunction of the left ventricle.Eur J Echocardiogr,2007,8:204-212.
  • 4邵肖梅,叶鸿瑁,丘小汕.实用新生儿学.第4版.北京:人民卫生出版社,2011.237.
  • 5Vuolteenaho O,Ala-Kopsala M,Ruskoaho H,et al.BNP as a biomarker in heart disease.Adv Clin Chem,2005,40:1-36.
  • 6Jankowski M.B-type natriuretic Peptide for diagnosis and therapy.Recent Pat Cardiovasc Drug Discov,2008,3:77-83.
  • 7Song BG,Jeon ES,Kim YH,et al.Correlation between levels of N-terminal pro-B-type natriuretic peptide and degrees of heart failure.Korean J Intern Med,2006,20:26-32.
  • 8Ezekowitz JA,Théroux P,Chang W,et al.N-terminal pro-brain natriuretic peptide and the timing,extent and mortality in ST elevation myocardial infarction.Can J Cardiol,2006,22:393-397.
  • 9Law YM,Hoyer AW,Reller MD,et al.Accuracy of plasma Btype natriuretic peptide to diagnose significant cardiovascular disease in childen:the better not pout children!Study.J Am Coll Cardiol,2009,54:1467-1475.
  • 10Heeschen C,Hamm CW,Mitrovic V,et al.N-terminal pro-Btype natriuretic peptide levels for dynamic risk stratification of patienst with acute coronary syndromes.Circulation,2004,110:3206-3212.

引证文献2

二级引证文献22

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部