降气平喘中药对哮喘患者可溶性IL-2受体表达及气道高反应性的影响

The Effects of Anti-asthmatic Traditional Chinese Medicine on SIL-2R Expression and Airway Hyperreactivity in Patients with Asthma

目的:观察降气平喘中药对哮喘患者可溶性白细胞介素-2受体(sIL-2R)表达及气道高反应性的影响。方法:60例缓解期哮喘患者分为中药组、强的松组、β-2受体组,分别于服药前后抽血,采用双抗体夹心ELASA测定sIL-2R,采用乙酰甲胆碱吸入法测定气道反应性。结果:中药组与强的松组sIL-2R与气道高反应性明显降低,治疗前后有非常显著性差异(P<0.01)。两组治疗后相比无统计学意义(P>0.05)。β_2组治疗前后的sIL-2R及气道反应性无明显变化(P>0.05)。结论:中药平喘剂通过降低患者sIL-2R及气道高反应性发挥抗炎平喘作用。

Objective: To investigate the effects of anti-asthmatic traditional Chinese medicine on soluble interleukin-2 receptors (sIL-2R)expression and airway hyperreactivity in patients with bronchial asthma. Methods: Sixty patients with asthma were divided into 3 groups:Traditional Chinese medicine(T) ,prednisone(P)and β2-adrenoceptor drug(β2)groups. Before and after treatment, the levels of sIL-2R in patients'blood sample and airway reaction to stimulator drug were measured respectively. Results:There were significant differences between pre- and post- treatment in T and P groups(P<0.01). But there was no difference after treatment between T and P groups (P < 0.05). There was no difference between pre- and post- treat-ment in ft group (P>0.05). Conclusion:Traditional Chinese medicine shown significant effects of antiinflammation on pa-tients with asthma by decreasing sIL-2R level and reducing airway hyperreactivity.